Immunogenetics

, Volume 53, Issue 10–11, pp 884–893

Unique TCR β-subunit variable gene haplotypes in Africans

  • Ian J. Donaldson
  • Jahan Shefta
  • Cathy A. Lawson
  • James R. Bushnell
  • Ann W. Morgan
  • John D. Isaacs
  • Danielle Carpenter
  • Marie-Anne Shaw
  • Ingegerd Rooth
  • Rupert J. Quinnell
  • Alimuddin M. Zumla
  • William E. Ollier
  • Chifumbe Z. Chintu
  • Gabriel P. Muyinda
  • Adrian V. Hill
  • Arthur W. Boylston
Original Paper

DOI: 10.1007/s00251-001-0406-8

Cite this article as:
Donaldson, I.J., Shefta, J., Lawson, C.A. et al. Immunogenetics (2002) 53: 884. doi:10.1007/s00251-001-0406-8
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Abstract.

This study investigated polymorphisms of genes in two regions of the T-cell antigen receptor β-subunit (TCRB) locus, including BV9S2P, and BV6S7 in a 5′ linkage group, and BV8S3, BV24S1, BV25S1, BV18S1, BV2S1, BV15S1 and BV3S1 in a 3′ linkage group. These loci have been genotyped in individuals from five regions in Africa, including The Gambia, Nigeria, Cameroon, Tanzania, and Zambia, and in individuals from northern Britain, northern India, and Papua New Guinea (PNG). In the 3′ linkage group, 11 unique haplotypes were identified in the combined African populations; two equally frequent haplotypes represent the majority of African chromosomes. One haplotype was found in all four regions studied. This is the most frequent haplotype in the northern British, northern Indian and PNG populations. Although present, it is infrequent in the African populations. A North-South gradient in the frequency of a common African haplotype was observed. The distribution did not represent that of a known disease. Evidence suggests that malaria is not responsible for selection of these haplotypes. Overall, this study highlights large differences in the genetic constitution of the TCRB locus between Africans and other populations.

T-cell antigen receptor Haplotype African Malaria Gradient 

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Ian J. Donaldson
    • 1
  • Jahan Shefta
    • 1
  • Cathy A. Lawson
    • 1
  • James R. Bushnell
    • 1
  • Ann W. Morgan
    • 1
  • John D. Isaacs
    • 1
  • Danielle Carpenter
    • 2
  • Marie-Anne Shaw
    • 2
  • Ingegerd Rooth
    • 3
  • Rupert J. Quinnell
    • 2
  • Alimuddin M. Zumla
    • 5
  • William E. Ollier
    • 6
  • Chifumbe Z. Chintu
    • 7
  • Gabriel P. Muyinda
    • 7
  • Adrian V. Hill
    • 8
  • Arthur W. Boylston
    • 1
  1. 1.Molecular Medicine Unit, Level 6, Clinical Sciences Building, St. James's University Hospital, Leeds, LS9 7TF, UK
  2. 2.School of Biology, University of Leeds, Leeds, LS2 9JT, UK
  3. 3.Division of Infectious Diseases, Karolinska Hospital, 171 76 Stockholm, Sweden
  4. 4.Nyamisati Malaria Research Unit, Rufiji District, Tanzania
  5. 5.UCL Medical School, Division of Infectious Diseases, The Rayne Institute, London, WC1E 6JJ, UK
  6. 6.ARC/ERU, Stopford Building, University of Manchester, Manchester, M13 9PL, UK
  7. 7.University of Zambia, Lusaka, Zambia
  8. 8.Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK

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