European Biophysics Journal

, Volume 26, Issue 2, pp 203–208 | Cite as

Stoichiometry of lipid-protein interaction and integral membrane protein structure

  • Derek Marsh


The stoichiometries of lipid-protein interaction obtained from spin label electron spin resonance experiments with integral membrane proteins are compared with simple geometric models for the intramembranous perimeter that are based on the predicted numbers of transmembrane helices. Deviations from the predicted values provide evidence for oligomerization of the protein in the membrane and/or more complex arrangements of the transmembrane segments.


Membrane Protein Electron Spin Resonance Electron Spin Geometric Model Spin Label 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Derek Marsh
    • 1
  1. 1.Max-Planck-Institut für biophysikalische Chemie, Abteilung Spektroskopie, Am Fassberg, D-37077 Göttingen, Germany (Fax: +49-551-201 1501)DE

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