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European Biophysics Journal

, Volume 47, Issue 4, pp 443–457 | Cite as

Quasispecies and virus

  • Esteban DomingoEmail author
  • Celia Perales
Original Article

Abstract

Quasispecies theory has been instrumental in the understanding of RNA virus population dynamics because it considered for the first time mutation as an integral part of the replication process. The key influences of quasispecies theory on experimental virology have been: (1) to disclose the mutant spectrum nature of viral populations and to evaluate its consequences; (2) to unveil collective properties of genome ensembles that can render a mutant spectrum a unit of selection; and (3) to identify new vulnerability points of pathogenic RNA viruses on three fronts: the need to apply multiple selective constraints (in the form of drug combinations) to minimize selection of treatment-escape variants, to translate the error threshold concept into antiviral designs, and to construct attenuated vaccine viruses through alterations of viral polymerase copying fidelity or through displacements of viral genomes towards unfavorable regions of sequence space. These three major influences on the understanding of viral pathogens preceded extensions of quasispecies to non-viral systems such as bacterial and tumor cell collectivities and prions. These developments are summarized here.

Keywords

Biological diversity Mutant spectrum Error-prone replication RNA genetics Lethal mutagenesis 

Notes

Acknowledgements

We are indebted to many colleagues and students that in our group have contributed to establish links between quasispecies theory and experimental virology. Work in Madrid was supported by Grants [BFU2011-23604, SAF2014-52400-R, SAF2017-87846-R, S2013/ABI-2906 (PLATESA from Comunidad de Madrid/FEDER)] and Fundación R. Areces, and Banco Santander. C.P. is supported by the Miguel Servet program of the Instituto de Salud Carlos III (CP14/00121) cofinanced by the European Regional Development Fund (ERDF).

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Copyright information

© European Biophysical Societies' Association 2018

Authors and Affiliations

  1. 1.Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Consejo Superior de Investigaciones Científicas (CSIC), Campus de CantoblancoMadridSpain
  2. 2.Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd)MadridSpain
  3. 3.Liver Unit, Internal Medicine, Laboratory of Malalties Hepàtiques, Vall d’Hebron Institut de Recerca-Hospital Universitari Vall d’Hebron (VHIR-HUVH)Universitat Autònoma de BarcelonaBarcelonaSpain

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