Acoustic levitation: recent developments and emerging opportunities in biomaterials research
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Containerless sample environments (levitation) are useful for study of nucleation, supercooling, and vitrification and for synthesis of new materials, often with non-equilibrium structures. Elimination of extrinsic nucleation by container walls extends access to supercooled and supersaturated liquids under high-purity conditions. Acoustic levitation is well suited to the study of liquids including aqueous solutions, organics, soft materials, polymers, and pharmaceuticals at around room temperature. This article briefly reviews recent developments and applications of acoustic levitation in materials R&D. Examples of experiments yielding amorphous pharmaceutical materials are presented. The implementation and results of experiments on supercooled and supersaturated liquids using an acoustic levitator at a high-energy X-ray beamline are described.
KeywordsAmorphous Glass Containerless processing Pharmaceutical API
This work was supported by the US DOE, at Argonne National Laboratory under contract number DE-AC02-06CH11357. We thank Dr Louis Hennet at CNRS-Orleans and Le Studium for travel assistance to participate in Cosmetics and Pharmaceutics: New Trends in Biophysical Approaches, Feb. 14–15, 2011, Orleans, France.
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