European Biophysics Journal

, 38:121

Transport at the nanoscale: temperature dependence of ion conductance

  • Catalin Chimerel
  • Liviu Movileanu
  • Soroosh Pezeshki
  • Mathias Winterhalter
  • Ulrich Kleinekathöfer
Biophysics Letter

Abstract

Temperature dependent ion conductance in nanopores is measured in a wide range of electrolyte concentrations and compared with molecular modeling. Single outer membrane protein F (OmpF) channels from E. coli are reconstituted into planar lipid bilayers. In qualitative agreement with the experimental data, applied-field molecular dynamics unraveled atomistic details of the ion transport. Comparing the temperature dependence of the channel conductance with that of the bulk conductivity in the range from 0 to 90°C revealed that at low salt concentrations the transport is mainly driven along the pore surface. Increasing the salt concentration saturates the surface charge transport and induces ion transport in the center of the nanopore. The confinement of the nanopore then favors the formation of ion pairs. Stepping up the temperature reduces the life time of the ion pairs and increases the channel conductance more than expected from the bulk behavior.

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Copyright information

© European Biophysical Societies' Association 2008

Authors and Affiliations

  • Catalin Chimerel
    • 1
  • Liviu Movileanu
    • 2
  • Soroosh Pezeshki
    • 1
  • Mathias Winterhalter
    • 1
  • Ulrich Kleinekathöfer
    • 1
  1. 1.School of Engineering and ScienceJacobs University BremenBremenGermany
  2. 2.Department of PhysicsSyracuse UniversitySyracuseUSA

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