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European Biophysics Journal

, Volume 38, Issue 3, pp 293–303 | Cite as

The mechano-gated K2P channel TREK-1

  • Alexandra Dedman
  • Reza Sharif-Naeini
  • Joost H. A. Folgering
  • Fabrice Duprat
  • Amanda Patel
  • Eric Honoré
Review

Abstract

The versatility of neuronal electrical activity is largely conditioned by the expression of different structural and functional classes of K+ channels. More than 80 genes encoding the main K+ channel alpha subunits have been identified in the human genome. Alternative splicing, heteromultimeric assembly, post-translational modification and interaction with auxiliary regulatory subunits further increase the molecular and functional diversity of K+ channels. Mammalian two-pore domain K+ channels (K2P) make up one class of K+ channels along with the inward rectifiers and the voltage- and/or calcium-dependent K+ channels. Each K2P channel subunit is made up of four transmembrane segments and two pore-forming (P) domains, which are arranged in tandem and function as either homo- or heterodimeric channels. This novel structural arrangement is associated with unusual gating properties including “background” or “leak” K+ channel activity, in which the channels show constitutive activity at rest. In this review article, we will focus on the lipid-sensitive mechano-gated K2P channel TREK-1 and will emphasize on the polymodal function of this “unconventional” K+ channel.

Keywords

Ion channels Stretch Mechanotransduction Potassium Pharmacology Physiology 

Notes

Acknowledgments

We are grateful to the ANR 2005 Cardiovasculaire-obésité-diabète, to the Association for Information and Research on Genetic Kidney Disease France, to the Fondation del Duca, to the Fondation de France, to the Fondation de la Recherche Médicale, to EEC Marie-Curie fellowships, to the Fondation de Recherche sur l’Hypertension Artérielle, to AFM, to HFSP to INSERM and to CNRS for support.

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Copyright information

© EBSA 2008

Authors and Affiliations

  • Alexandra Dedman
    • 1
  • Reza Sharif-Naeini
    • 1
  • Joost H. A. Folgering
    • 1
  • Fabrice Duprat
    • 1
  • Amanda Patel
    • 1
  • Eric Honoré
    • 1
  1. 1.Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR 6097Université de Nice-Sophia AntipolisValbonneFrance

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