European Biophysics Journal

, Volume 36, Issue 2, pp 163–171 | Cite as

Study of the dynamical properties of water in disaccharide solutions

  • S. MagazùEmail author
  • F. Migliardo
  • M. T. F. Telling
Biophysics Letter


This work presents quasi-elastic neutron scattering (QENS) and neutron spin echo (NSE) findings on homologous disaccharide (i.e. trehalose, maltose and sucrose)/water solutions as a function of temperature. The dynamical properties of these systems are investigated by QENS, which, on the picosecond scale, allows for the characterisation of the diffusion of both solutes and solvent. On the other hand, NSE investigates the dynamics on the nanosecond scale, allowing for the relaxation times of the disaccharide/water systems to be evaluated. The experimental data highlight a strong slowing down of water in the presence of disaccharides. The whole set of findings indicates, therefore, a noticeable disaccharide–water interaction, which is more intense in the case of trehalose. This feature can justify its higher bioprotective effectiveness.


Trehalose Disaccharide Hydration Number High Glass Transition Temperature Dynamical Structure Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors gratefully acknowledge the ISIS facility for the dedicated runs at the IRIS spectrometer and the BENSC facility for the dedicated runs at the V5 spectrometer.


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Copyright information

© EBSA 2006

Authors and Affiliations

  1. 1.Dipartimento di FisicaUniversità di MessinaMessinaItaly
  2. 2.ISIS FacilityRutherford Appleton LaboratoryDidcotUK

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