European Biophysics Journal

, Volume 35, Issue 5, pp 446–450

Targeting cancer cells: magnetic nanoparticles as drug carriers

  • Christoph Alexiou
  • Roswitha J. Schmid
  • Roland Jurgons
  • Marcus Kremer
  • Gerhard Wanner
  • Christian Bergemann
  • Ernst Huenges
  • Thomas Nawroth
  • Wolfgang Arnold
  • Fritz G. Parak
Biophysics Letter

DOI: 10.1007/s00249-006-0042-1

Cite this article as:
Alexiou, C., Schmid, R.J., Jurgons, R. et al. Eur Biophys J (2006) 35: 446. doi:10.1007/s00249-006-0042-1

Abstract

Magnetic drug targeting employing nanoparticles as carriers is a promising cancer treatment avoiding side effects of conventional chemotherapy. We used iron oxide nanoparticles covered by starch derivatives with phosphate groups which bound mitoxantrone as chemotherapeutikum. In this letter we show that a strong magnetic field gradient at the tumour location accumulates the nanoparticles. Electron microscope investigations show that the ferrofluids can be enriched in tumour tissue and tumour cells.

Keywords

Cell biophysics Biological tissue Microscopy 

Copyright information

© EBSA 2006

Authors and Affiliations

  • Christoph Alexiou
    • 1
  • Roswitha J. Schmid
    • 1
  • Roland Jurgons
    • 1
  • Marcus Kremer
    • 2
  • Gerhard Wanner
    • 3
  • Christian Bergemann
    • 4
  • Ernst Huenges
    • 5
  • Thomas Nawroth
    • 5
  • Wolfgang Arnold
    • 6
  • Fritz G. Parak
    • 5
  1. 1.Klinik und Poliklinik für Hals- Nasen- Ohren- kranke, Universität Erlangen – NürnbergErlangenGermany
  2. 2.Institut für Pathologie, Klinikum rechts der Isar, TUMMunichGermany
  3. 3.Fakultät für Biologie I der LMU LMU MunichGermany
  4. 4.chemicellBerlinGermany
  5. 5.Physik - Department E17TUMMunichGermany
  6. 6.Hals- Nasen- Ohrenklinik und Polyklinik rechts der Isar, TUMMunichGermany

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