European Biophysics Journal

, Volume 34, Issue 8, pp 1066–1070 | Cite as

Amphiphile-induced tubular budding of the bilayer membrane

  • Veronika Kralj-Iglič
  • Henry Hägerstrand
  • Peter Veranič
  • Kristijan Jezernik
  • Blaž Babnik
  • Dorit R. Gauger
  • Aleš Iglič
Biophysics Letter

Abstract

Amphiphile-induced tubular budding of the erythrocyte membrane was studied using transmission electron microscopy. No chiral patterns of the intramembraneous particles were found, either on the cylindrical buds, or on the tubular nanoexovesicles. In agreement with these observations, the tubular budding may be explained by in-plane ordering of anisotropic membrane inclusions in the buds where the difference between the principal membrane curvatures is very large. In contrast to previously reported theories, no direct external mechanical force is needed to explain tubular budding of the bilayer membrane.

Keywords

Tubular budding Amphiphiles Nanotubes Freeze-fracture electron microscopy Deviatoric elasticity 

Notes

Acknowledgements

Stimulating discussions with Hans U. Lutz and Sylvio May are gratefully acknowledged. The Åbo Akademy University supported the stay of A.I. at Åbo Akademy University in Åbo/Turku.

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Copyright information

© EBSA 2005

Authors and Affiliations

  • Veronika Kralj-Iglič
    • 1
    • 4
  • Henry Hägerstrand
    • 2
  • Peter Veranič
    • 3
  • Kristijan Jezernik
    • 3
  • Blaž Babnik
    • 4
  • Dorit R. Gauger
    • 5
  • Aleš Iglič
    • 4
  1. 1.Institute of Biophysics, Faculty of MedicineUniversity of LjubljanaLjubljanaSlovenia
  2. 2.Department of BiologyÅbo Akademi UniversityÅbo/TurkuFinland
  3. 3.Institute of Cell Biology, Faculty of MedicineUniversity of LjubljanaLjubljanaSlovenia
  4. 4.Laboratory of Physics, Faculty of Electrical EngineeringUniversity of LjubljanaLjubljanaSlovenia
  5. 5.Friedrich Schiller UniversityJenaGermany

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