Ecological Strategies Behind the Selection of Cultivable Actinomycete Strains from the Yucatan Peninsula for the Discovery of Secondary Metabolites with Antibiotic Activity
The quest for novel natural products has recently focused on the marine environment as a source for novel microorganisms. Although isolation of marine-derived actinomycete strains is now common, understanding their distribution in the oceans and their adaptation to this environment can be helpful in the selection of isolates for further novel secondary metabolite discovery. This study explores the taxonomic diversity of marine-derived actinomycetes from distinct environments in the coastal areas of the Yucatan Peninsula and their adaptation to the marine environment as a first step towards novel natural product discovery. The use of simple ecological principles, for example, phylogenetic relatedness to previously characterized actinomycetes or seawater requirements for growth, to recognize isolates with adaptations to the ocean in an effort to select for marine-derived actinomycete to be used for further chemical studies. Marine microbial environments are an important source of novel bioactive natural products and, together with methods such as genome mining for detection of strains with biotechnological potential, ecological strategies can bring useful insights in the selection and identification of marine-derived actinomycetes for novel natural product discovery.
KeywordsNatural product discovery Marine sediments Marine Actinomycetes Marine microbial ecology
Authors would like to acknowledge Dr. Emanuel Hernández-Núñez at the Department for Marine Resourcesin CINVESTAV, Mérida for his help with the GC-MS analysis of the crude extracts.
Parera-Valadez contributed by heading the research and writing the paper. Yam-Puc and Figueroa-Saldivar contributed with chemical analyses, bioautography assays, and manuscript writing. López-Aguiar and Márquez-Velázquez contributed with field collections, laboratory procedures, and manuscript revisions. Borges-Argáez and Cáceres-Farfán contributed with bioautography assays.
We would like to recognize the Mexican Council of Science and Technology (CONACyT) for their support through fellowships for Parera-Valadez (Masters in Science fellowship: 560614) and Yam-Puc (Postdoctoral fellowship). We would like to recognize the National Autonomous University of Mexico (UNAM) for their funding through PAPIIT TA200212 and TA200415 and UNAM School of Chemistry for their funding through PAIP.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
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