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Pediatric Radiology

, Volume 49, Issue 13, pp 1848–1849 | Cite as

Hermes

Hermes
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Kidney biopsy findings in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study

Zahr RS, Yee ME, Weaver J et al

Pediatr Nephrol (2019)34:1435–1445

Sickle cell disease (SCD) results in the production of HBSS (hemoglobin SS) in homozygous patients, which in turn leads to erythrocyte sickling, hemolysis and endothelial damage in affected individuals. Renal damage in children with HBSS is believed to start as early as the first decade of life, with albuminuria present in roughly 20% of homozygous children. End-stage renal disease eventually develops in 418% of patients. To determine the types and extent of renal injury in children with SCD, the authors of this multi-institutional retrospective investigation reviewed the results of renal biopsies in 36 patients with a median age of 12.5 years (range 419 years). Median follow-up was 2.6 years (range 0.410.4 years). The most common indication for biopsy among the patients was proteinuria, which fell into the...

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© Springer-Verlag GmbH Germany, part of Springer Nature 2019

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