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Evaluation of incidental pelvic fluid in relation to physiological changes in healthy pubescent children using pelvic magnetic resonance imaging

  • Ashkan Tadayoni
  • Faraz Farhadi
  • S. Mojdeh Mirmomen
  • Ahmad Shafiei
  • Karen F. Berman
  • Mohammadhadi Bagheri
  • Pedro E. Martinez
  • Peter J. Schmidt
  • Jack A. Yanovski
  • Ashkan A. MalayeriEmail author
Original Article

Abstract

Background

Peritoneal free fluid can indicate an underlying disease process; however detection of minimal peritoneal free fluid in healthy children is not uncommon.

Objective

To assess the significance of incidental peritoneal free fluid within healthy children by MRI and its relation to physiological changes during puberty.

Materials and methods

This prospective study was performed on 32 healthy volunteers (20 boys) between the ages of 8 years and 13 years, with consecutive follow-ups every 8–10 months for an average of 3 years. Body mass index (BMI) z-score, pubertal status, C-reactive protein and sex hormone concentrations were assessed prior to MRI studies. We reviewed a total of 120 pelvic MRI studies (61 boys) and measured the quantity of peritoneal free fluid. For statistical analysis we used linear mixed-model accounting for within-patient correlations.

Results

The mean ± standard deviation volume of peritoneal free fluid was 4.7±5.7 mL in girls and 1.9±3.1 mL in boys, with a maximum volume of 25 mL and 17 mL, respectively. The prevalence of peritoneal free fluid was significantly higher in girls (91%) compared to boys (67%; P=0.0035). In 15% of the girls and 3% of the boys the fluid was greater than 10 mL. The mean volume of peritoneal free fluid in the fourth stage of puberty was higher and significantly different from the mean volume in the first stage of puberty (P=0.01).

Conclusion

Among healthy pubescent children, the prevalence of peritoneal free fluid is significantly higher in girls. The volume of peritoneal free fluid can reach volumes greater than 10 mL during normal puberty, especially in the fourth stage, and can be assumed normal in the absence of active disease.

Keywords

Children Magnetic resonance imaging Normal values Pelvis Peritoneal free fluid Pubertal stage 

Notes

Compliance with ethical standards

Conflicts of interest

None

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Copyright information

© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2019

Authors and Affiliations

  • Ashkan Tadayoni
    • 1
  • Faraz Farhadi
    • 1
  • S. Mojdeh Mirmomen
    • 1
  • Ahmad Shafiei
    • 1
  • Karen F. Berman
    • 2
  • Mohammadhadi Bagheri
    • 1
  • Pedro E. Martinez
    • 3
  • Peter J. Schmidt
    • 3
  • Jack A. Yanovski
    • 2
  • Ashkan A. Malayeri
    • 4
    Email author
  1. 1.Radiology and Imaging Sciences, Clinical CenterNational Institutes of HealthBethesdaUSA
  2. 2.Clinical Translational Neuroscience Branch at the National Institute of Mental HealthNational Institutes of HealthBethesdaUSA
  3. 3.Section on Behavioral Endocrinology, National Institute of Mental Health, Department of Health and Human ServicesNational Institutes of HealthBethesdaUSA
  4. 4.Department of RadiologyBrigham and Women’s HospitalBostonUSA

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