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Pediatric Radiology

, Volume 49, Issue 1, pp 68–75 | Cite as

Validation of cardiac magnetic-resonance-derived left ventricular strain measurements from free-breathing motion-corrected cine imaging

  • Anthony MerloccoEmail author
  • Russell R. Cross
  • Peter Kellman
  • Hui Xue
  • Laura Olivieri
Original Article

Abstract

Background

Myocardial strain is an important measure of cardiac function and can be assessed on cardiac magnetic resonance (MR) through the current gold standard of breath-held segmented steady-state free precession (SSFP) cine imaging. Novel free-breathing techniques have been validated for volumetry and systolic function, allowing for evaluation of sicker and younger children who cannot reliably hold their breath. It is unclear whether strain measurements can be reliably performed on free-breathing, motion-corrected, re-binning cine images.

Objective

To compare strain analysis from motion-corrected retrospective re-binning images to the breath-held SSFP cine images to explore their validity.

Materials and methods

Twenty-five children and young adults, ages (2.1–18.6 years) underwent breath-held and motion-corrected retrospective re-binning cine techniques during the same MR examination on a 1.5-tesla magnet. We measured endocardial end-systolic global circumferential strain and endocardial averaged segmental strain using commercial software (MEDIS QStrain 2.1). We used Pearson correlation coefficients to test agreement across techniques.

Results

Analysis was possible in all 25 breath-held and motion-corrected retrospective re-binning studies. Global circumferential strain and endocardial averaged segmental strain obtained by motion-corrected retrospective re-binning compared favorably to breath-held studies. Global circumferential strain linear regression models demonstrated acceptable agreement, with coefficients of determination of 0.75 for breath-held compared to motion-corrected retrospective re-binning (P<0.001) and for endocardial averaged segmental strain comparisons yielded 0.77 for breath-held vs. motion-corrected retrospective re-binning (P<0.001). Bland–Altman assessment demonstrated minimal bias for breath-held compared to motion-corrected retrospective re-binning (mean 2.4 and 1.9, respectively, for global circumferential strain and endocardial averaged segmental strain).

Conclusion

Free-breathing imaging by motion-corrected retrospective re-binning cine imaging provides adequate spatial and temporal resolution to measure myocardial deformation when compared to the gold-standard breath-held SSFP cine imaging in children with normal or borderline systolic function.

Keywords

Children Heart Magnetic resonance imaging Motion correction Real-time imaging Retrospective reconstruction Strain imaging 

Notes

Acknowledgments

This research was supported by the Intramural Research Program of the National Institutes of Health, National Heart, Lung, and Blood Institute. The authors wish to thank Michael Hansen, PhD, for his work through the National Institutes of Health/NHLBI. The contributions through development and implementation of the motion-corrected free-breathing re-binning technique made this work possible.

Compliance with ethical standards

Conflicts of interest

None

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Cardiology, Children’s National Health System, Department of PediatricsGeorge Washington Medical SchoolWashingtonUSA
  2. 2.Division of Cardiology, Le Bonheur Children’s Hospital, Department of PediatricsUniversity of Tennessee Health Science CenterMemphisUSA
  3. 3.National Heart, Lung, and Blood Institute, National Institutes of HealthBethesdaUSA

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