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Pediatric Radiology

, Volume 48, Issue 10, pp 1432–1440 | Cite as

Can diffusion weighting replace gadolinium enhancement in magnetic resonance enterography for inflammatory bowel disease in children?

  • Farah Khachab
  • Anderson Loundou
  • Céline Roman
  • Nathalie Colavolpe
  • Audrey Aschero
  • Brigitte Bourlière-Najean
  • Nassima Daidj
  • Catherine Desvignes
  • Harmony Pico
  • Guillaume Gorincour
  • Pascal Auquier
  • Philippe Petit
Original Article

Abstract

Background

Contrast-enhanced MRI is often used for diagnosis and follow-up of children with inflammatory bowel disease.

Objective

To compare the accuracy of diffusion-weighted MRI (DWI) to contrast-enhanced MRI in children with known or suspected inflammatory bowel disease.

Materials and methods

This retrospective, consecutive study included 55 children. We used ileo-colonoscopy and histology as the reference standard from the terminal ileum to the rectum, and contrast-enhanced MRI as the reference standard proximal to the terminal ileum. DWI and contrast-enhanced MRI sequences were independently reviewed and compared per patient and per segment to these reference standards and to the follow-up for each child.

Results

We obtained endoscopic data for 340/385 colonic and ileal segments (88%). The rate of agreement per segment between DWI and endoscopy was 64%, and the rate of agreement between contrast-enhanced MRI and endoscopy was 59%. Per patient, sensitivity and specificity of bowel wall abnormalities as compared to the endoscopy were 87% and 100% for DWI, and 70% and 100% for contrast-enhanced MRI, respectively. Positive and negative predictive values were, respectively, 100% and 57% for DWI, and 96% and 41% for contrast-enhanced MRI. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of DWI compare to contrast-enhanced MRI in the segments proximal to the terminal ileum were 90%, 98%, 90%, 98% and 96%, respectively.

Conclusion

The diagnostic performance of DWI is competitive to that of contrast-enhanced MRI in children with known or suspected inflammatory bowel disease.

Keywords

Adolescent Children Contrast-enhancement Diffusion-weighted imaging Gadolinium Inflammatory bowel diseases Magnetic resonance imaging 

Notes

Compliance with ethical standards

Conflicts of interest

None

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Farah Khachab
    • 1
  • Anderson Loundou
    • 2
  • Céline Roman
    • 3
  • Nathalie Colavolpe
    • 1
  • Audrey Aschero
    • 1
  • Brigitte Bourlière-Najean
    • 1
  • Nassima Daidj
    • 1
  • Catherine Desvignes
    • 1
  • Harmony Pico
    • 1
  • Guillaume Gorincour
    • 1
  • Pascal Auquier
    • 2
  • Philippe Petit
    • 1
  1. 1.Pediatric Radiology Department, Hopital de la TimoneAssistance Publique des Hopitaux de MarseilleMarseille Cedex 5, MarseilleFrance
  2. 2.Public Health Department, Hopital de la TimoneAssistance Publique des Hopitaux de MarseilleMarseilleFrance
  3. 3.Pediatric Gastroenterology Department, Hopital de la TimoneAssistance Publique des Hopitaux de MarseilleMarseilleFrance

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