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Evaluation of blood flow distribution asymmetry and vascular geometry in patients with Fontan circulation using 4-D flow MRI

Abstract

Background

Asymmetrical caval to pulmonary blood flow is suspected to cause complications in patients with Fontan circulation. The aim of this study was to test the feasibility of 4-D flow MRI for characterizing the relationship between 3-D blood flow distribution and vascular geometry.

Objective

We hypothesized that both flow distribution and geometry can be calculated with low interobserver variability and will detect a direct relationship between flow distribution and Fontan geometry.

Materials and methods

Four-dimensional flow MRI was acquired in 10 Fontan patients (age: 16 ± 4 years [mean ± standard deviation], range: 9–21 years). The Fontan connection was isolated by 3-D segmentation to evaluate flow distribution from the inferior vena cava (IVC) and superior vena cava (SVC) to the left and right pulmonary arteries (LPA, RPA) and to characterize geometry (cross-sectional area, caval offset, vessel angle).

Results

Flow distribution results indicated SVC flow tended toward the RPA while IVC flow was more evenly distributed (SVC to RPA: 78% ± 28 [9–100], IVC to LPA: 54% ± 28 [4–98]). There was a significant relationship between pulmonary artery cross-sectional area and flow distribution (IVC to RPA: R2=0.50, P=0.02; SVC to LPA: R2=0.81, P=0.0004). Good agreement was found between observers and for flow distribution when compared to net flow values.

Conclusion

Four-dimensional flow MRI was able to detect relationships between flow distribution and vessel geometry. Future studies are warranted to investigate the potential of patient specific hemodynamic analysis to improve diagnostic capability.

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Acknowledgments

We would like to acknowledge Maya Gabbour, M.D., Samantha E. Schoeneman, B.A., and Ryan Kuhn, B.S., from the Department of Medical Imaging, Ann & Robert H. Lurie Children’s Hospital of Chicago, for their contributions in data management and patient recruitment. We received grant support from the National Institutes of Health (R01HL115828) and American Heart Association (14PRE18620016).

Author information

Correspondence to Kelly Jarvis.

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Electronic supplementary material

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Three-dimensional blood flow visualization in a patient with Fontan circulation (patient 5, a 16-year-old boy status post extracardiac Fontan). (MPG 45906 kb)

Supporting video S1

Three-dimensional blood flow visualization in a patient with Fontan circulation (patient 5, a 16-year-old boy status post extracardiac Fontan). (MPG 45906 kb)

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Jarvis, K., Schnell, S., Barker, A.J. et al. Evaluation of blood flow distribution asymmetry and vascular geometry in patients with Fontan circulation using 4-D flow MRI. Pediatr Radiol 46, 1507–1519 (2016) doi:10.1007/s00247-016-3654-3

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Keywords

  • Cardiovascular magnetic resonance
  • Children
  • Congenital heart disease
  • Fontan
  • Four-dimensional flow magnetic resonance imaging
  • Heart