Validation of automatic bone age determination in children with congenital adrenal hyperplasia
- 267 Downloads
Determination of bone age is routinely used for following up substitution therapy in congenital adrenal hyperplasia (CAH) but today is a procedure with significant subjectivity.
The aim was to test the performance of automatic bone age rating by the BoneXpert software package in all radiographs of children with CAH seen at our clinic from 1975 to 2006.
Materials and methods
Eight hundred and ninety-two left-hand radiographs from 100 children aged 0 to 17 years were presented to a human rater and BoneXpert for bone age rating. Images where ratings differed by more than 1.5 years were each rerated by four human raters.
Rerating was necessary in 20 images and the rerating result was closer to the BoneXpert result than to the original manual rating in 18/20 (90 %). Bone age rating precision based on the smoothness of longitudinal curves comprising a total of 327 data triplets spanning less than 1.7 years showed BoneXpert to be more precise (P<0.001).
BoneXpert performs reliable bone age ratings in children with CAH.
KeywordsCongenital adrenal hyperplasia Skeletal maturation Bone age rating Glucocorticoid substitution
Conflicts of interest
- 3.Pang SY, Wallace MA, Hofman L et al (1998) Worldwide experience in newborn screening for classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Pediatrics 81:866–874Google Scholar
- 18.Martin DD, Meister K, Schweizer R et al (2008) Validation of automatic bone age rating in children with precocious and early puberty. J Pediatr Endocrinol Metab. 2011;24(11-12):1009–1014Google Scholar