Pediatric Radiology

, Volume 43, Issue 1, pp 15–27

Diffusion tensor imaging of normal brain development

  • Shoko Yoshida
  • Kenichi Oishi
  • Andreia V. Faria
  • Susumu Mori


Diffusion tensor imaging (DTI) is an MRI technique that can measure the macroscopic structural organization in brain tissues. DTI has been shown to provide information complementary to relaxation-based MRI about the changes in the brain’s microstructure. In the pediatric population, DTI enables quantitative observation of the maturation process of white matter structures. Its ability to delineate various brain structures during developmental stages makes it an effective tool with which to characterize both the normal and abnormal anatomy of the developing brain. This review will highlight the advantages, as well as the common technical pitfalls of pediatric DTI. In addition, image quantification strategies for various DTI-derived parameters and the normal brain developmental changes associated with these parameters are discussed.


Diffusion tensor imaging (DTI) MRI Normal development 


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Shoko Yoshida
    • 1
  • Kenichi Oishi
    • 2
  • Andreia V. Faria
    • 2
  • Susumu Mori
    • 3
    • 4
  1. 1.The Russell H. Morgan Department of Radiology and Radiological ScienceThe Johns Hopkins University School of MedicineBaltimoreUSA
  2. 2.The Russell H. Morgan Department of Radiology and Radiological ScienceThe Johns Hopkins University School of MedicineBaltimoreUSA
  3. 3.The Russell H. Morgan Department of Radiology and Radiological ScienceThe Johns Hopkins University School of MedicineBaltimoreUSA
  4. 4.F. M. Kirby Research Center for Functional Brain ImagingKennedy Krieger InstituteBaltimoreUSA

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