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Pediatric Radiology

, Volume 40, Issue 5, pp 670–673 | Cite as

Tracheal side effects following fetal endoscopic tracheal occlusion for severe congenital diaphragmatic hernia

  • Jan DeprestEmail author
  • Luc Breysem
  • Eduardo Gratacos
  • Kypros Nicolaides
  • Filip Claus
  • Anne Debeer
  • Maria Helena Smet
  • Marijke Proesmans
  • Pierre Fayoux
  • Laurent Storme
Commentary

Despite optimal neonatal care and even in large referral centres, between 20% and 30% of neonates with isolated congenital diaphragmatic hernia (CDH) will not survive [1]. The leading causes of death remain in essence pulmonary hypoplasia and persistent pulmonary hypertension (PPHT). Prenatal medical imaging methods are used to predict individual outcome, which provides parents with prenatal options. For those with a predicted poor outcome this might include prenatal intervention, which aims to improve lung development rather than repairing the anatomical defect. Early attempts by prenatal surgical repair of the defect were abandoned as they required access by hysterotomy and because reducing liver herniation compromises the fetal circulation [2]. Tracheal occlusion (TO) prevents egress of lung liquid produced by the airway epithelium, hence induces tissue stretch, which acts as a signal for lung growth [3, 4]. Clinically TO was initially performed using extra-luminal clips with...

Keywords

Congenital Diaphragmatic Hernia Congenital Diaphragmatic Hernia Lung Growth Tracheal Occlusion Balloon Removal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The FETO programme is in part supported by the European Commission (EuroSTEC, 6th Framework, LSHC-CT-2006-037409) and the Flemish Community of Belgium (IWT/ 070715). JDP is a “clinical researcher” of the Fonds voor Wetenschappelijk Onderzoek Vlaanderen (1.8.012.07.N.02). AD is a clinical researcher supported by the KOOR funds of the University Hospitals Leuven.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Jan Deprest
    • 1
    • 4
    • 8
    Email author
  • Luc Breysem
    • 5
  • Eduardo Gratacos
    • 1
    • 2
  • Kypros Nicolaides
    • 1
    • 3
  • Filip Claus
    • 5
  • Anne Debeer
    • 4
  • Maria Helena Smet
    • 5
  • Marijke Proesmans
    • 4
  • Pierre Fayoux
    • 6
  • Laurent Storme
    • 7
  1. 1.FETO ConsortiumLeuven-Barcelona-London
  2. 2.Hospital ClinicBarcelonaSpain
  3. 3.King’s CollegeLondonUK
  4. 4.Department Woman and ChildUniversity Hospitals LeuvenLeuvenBelgium
  5. 5.Department Medical ImagingUniversity Hospitals LeuvenLeuvenBelgium
  6. 6.Department of Pediatric OtorhinolaryngologyCHRU Jeanne de FlandreLilleFrance
  7. 7.Department PerinatologyCHRU Jeanne de FlandreLilleFrance
  8. 8.Department Woman and Child, Division WomanUniversity Hospital LeuvenLeuvenBelgium

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