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Pediatric Radiology

, Volume 40, Issue 2, pp 153–162 | Cite as

Digital atlas of fetal brain MRI

  • Teresa ChapmanEmail author
  • Manuela Matesan
  • Ed Weinberger
  • Dorothy I. Bulas
Original Article

Abstract

Background

Fetal MRI can be performed in the second and third trimesters. During this time, the fetal brain undergoes profound structural changes. Interpretation of appropriate development might require comparison with normal age-based models. Consultation of a hard-copy atlas is limited by the inability to compare multiple ages simultaneously.

Objective

To provide images of normal fetal brains from weeks 18 through 37 in a digital format that can be reviewed interactively. This will facilitate recognition of abnormal brain development.

Materials and methods

T2-W images for the atlas were obtained from fetal MR studies of normal brains scanned for other indications from 2005 to 2007. Images were oriented in standard axial, coronal and sagittal projections, with laterality established by situs. Gestational age was determined by last menstrual period, earliest US measurements and sonogram performed on the same day as the MR. The software program used for viewing the atlas, written in C#, permits linked scrolling and resizing the images. Simultaneous comparison of varying gestational ages is permissible.

Results

Fetal brain images across gestational ages 18 to 37 weeks are provided as an interactive digital atlas and are available for free download from http://radiology.seattlechildrens.org/teaching/fetal_brain.

Conclusion

Improved interpretation of fetal brain abnormalities can be facilitated by the use of digital atlas cataloging of the normal changes throughout fetal development. Here we provide a description of the atlas and a discussion of normal fetal brain development.

Keywords

Fetal Neuroradiology Development MRI 

References

  1. 1.
    Garel C, Brisse H, Sebag G et al (1998) Magnetic resonance imaging of the fetus. Pediatr Radiol 28:201–211CrossRefPubMedGoogle Scholar
  2. 2.
    Garel C (2006) New advances in fetal MR neuroimaging. Pediatr Radiol 36:621–625CrossRefPubMedGoogle Scholar
  3. 3.
    Sandrasegaran K, Lall CG, Aisen AA (2006) Fetal magnetic resonance imaging. Curr Opin Obstet Gynecol 18:605–612CrossRefPubMedGoogle Scholar
  4. 4.
    Adamsbaum C (ed) (2001) Atlas d’IRM du cerveau foetal. Masson, ParisGoogle Scholar
  5. 5.
    Garel C (ed) (2004) MRI of the fetal brain. Normal development and cerebral pathologies. Springer, BerlinGoogle Scholar
  6. 6.
    deRegt D, Jelacic S, Weinberger E (2006) Interactive digital MR atlas of the pediatric brain. Radiographics 26:497–501CrossRefGoogle Scholar
  7. 7.
    Encha-Razavi F, Sonigo P (2003) Features of the developing brain. Childs Nerv Syst 19:426–428CrossRefPubMedGoogle Scholar
  8. 8.
    Hansen PE, Ballesteros MC, Soila K et al (1993) MR imaging of the developing brain. Part 1. Prenatal development. Radiographics 13:21–36PubMedGoogle Scholar
  9. 9.
    Chi JG, Dooling EC, Gilles FH (1977) Gyral development of the human brain. Ann Neurol 1:86–93CrossRefPubMedGoogle Scholar
  10. 10.
    Dorovini-Zis K, Dolman CL (1977) Gestational development of brain. Arch Pathol Lab Med 101:192–195PubMedGoogle Scholar
  11. 11.
    Larroche JC (1981) Morphological criteria of central nervous system development in the human foetus. J Neuroradiol 8:93–108PubMedGoogle Scholar
  12. 12.
    Garel C, Chantrel E, Brisse H et al (2001) Fetal cerebral cortex: normal gestational landmarks identified using prenatal MR imaging. AJNR 22:184–189PubMedGoogle Scholar
  13. 13.
    Levine D, Barnes PD (1999) Cortical maturation in normal and abnormal fetuses as assessed with prenatal MR imaging. Radiology 210:751–758PubMedGoogle Scholar
  14. 14.
    Lan LM, Yamashita Y, Tang Y et al (2000) Normal fetal brain development: MR imaging with a half-fourier rapid acquisition with relaxation enhancement sequence. Radiology 215:205–210PubMedGoogle Scholar
  15. 15.
    Garel C, Chantrel E, Elmaleh M (2003) Fetal MRI: normal gestational landmarks for cerebral biometry, gyration and myelination. Childs Nerv Syst 19:422–425CrossRefPubMedGoogle Scholar
  16. 16.
    Glenn OA, Barkovich AJ (2006) Magnetic resonance imaging of the fetal brain and spine: an increasingly important tool in prenatal diagnosis, part 1. AJNR 27:1604–1611PubMedGoogle Scholar
  17. 17.
    Girard N, Raybaud C, Poncet M (1995) In vivo MR study of brain maturation in normal fetuses. AJNR 16:407–413PubMedGoogle Scholar
  18. 18.
    VanderKnaap MS, VanWezel-Meijler G, Barth PG et al (1996) Normal gyration and sulcation in preterm and term neonates: appearance on MR images. Radiology 200:389–396Google Scholar
  19. 19.
    Brisse H, Fallet C, Sebag G et al (1997) Supratentorial parenchyma in the developing fetal brain: in vivo MR study with histologic comparison. AJNR 18:1491–1497PubMedGoogle Scholar
  20. 20.
    Girard N, Raybaud C, Poncet M (1995) In vivo MR study of brain maturation in normal fetuses. AJNR 16:407–413PubMedGoogle Scholar
  21. 21.
    Mintz MC, Grossman RI, Isaacson G et al (1987) MR imaging of fetal brain. J Comput Assist Tomogr 11:120–123CrossRefPubMedGoogle Scholar
  22. 22.
    Robinson AJ, Blaser S, Toi A et al (2007) The fetal cerebellar vermis: assessment for abnormal development by ultrasonography and magnetic resonance imaging. Ultrasound Quar 23:211–223CrossRefGoogle Scholar
  23. 23.
    Oh KY, Rassner UA, Frias AE et al (2007) The fetal posterior fossa: clinical correlation of findings on prenatal ultrasound and fetal magnetic resonance imaging. Ultrasound Quar 23:203–210CrossRefGoogle Scholar
  24. 24.
    Triulzi F, Parazzini C, Righini A (2006) Magnetic resonance imaging of fetal cerebellar development. Cerebellum 5:199–205CrossRefPubMedGoogle Scholar
  25. 25.
    Cardoza JD, Goldstein RB, Filly RA (1988) Exclusion of fetal ventriculomegaly with a single measurement: the width of the lateral ventricular atrium. Radiology 169:711–714PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Teresa Chapman
    • 1
    Email author
  • Manuela Matesan
    • 2
  • Ed Weinberger
    • 1
  • Dorothy I. Bulas
    • 3
  1. 1.Seattle Children’s HospitalDepartment of RadiologySeattleUSA
  2. 2.Department of RadiologyUniversity of WashingtonSeattleUSA
  3. 3.Children’s National Medical CenterDivision of Diagnostic Imaging and RadiologyWashington, DCUSA

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