Pediatric Radiology

, Volume 39, Issue 2, pp 164–167 | Cite as

Primary hypothyroidism mimicking a pituitary macroadenoma: regression after thyroid hormone replacement therapy

  • Ki Seong Eom
  • Choi See-Sung
  • Jong Duck Kim
  • Jong Moon Kim
  • Tae Young Kim
Case Report


We report a 9-year-old girl with pituitary hyperplasia due to primary hypothyroidism. She presented with growth arrest, abnormal thyroid function studies, and a pituitary mass on MRI. With thyroxine therapy, the pituitary mass regressed and her symptoms resolved. Primary hypothyroidism should be considered in the differential diagnosis of solid mass lesions of the pituitary gland.


Hypothyroidism Pituitary adenoma Pituitary hyperplasia 



This work was supported by Wonkwang Institute of Clinical Medicine in 2008.


  1. 1.
    Joshi AS, Woolf PD (2005) Pituitary hyperplasia secondary to primary hypothyroidism: a case report and review of the literature. Pituitary 8:99–103PubMedCrossRefGoogle Scholar
  2. 2.
    Koller KJ, Wolff RS, Warden MK (1987) Thyroid hormones regulate levels of thyrotropin-releasing-hormone mRNA in the paraventricular nucleus. Proc Natl Acad Sci U S A 84:7329–7333PubMedCrossRefGoogle Scholar
  3. 3.
    Beck-Peccoz P, Brucker-Davis F, Persani L (1996) Thyrotropin-secreting pituitary tumors. Endocr Rev 17:610–638PubMedCrossRefGoogle Scholar
  4. 4.
    Khawaja NM, Taher BM, Barham ME (2006) Pituitary enlargement in patients with primary hypothyroidism. Endocr Pract 12:29–34PubMedGoogle Scholar
  5. 5.
    Shimono T, Hatabu H, Kasagi K (1999) Rapid progression of pituitary hyperplasia in humans with primary hypothyroidism: demonstration with MR imaging. Radiology 213:383–388PubMedGoogle Scholar
  6. 6.
    Connor SE, Penney CC (2003) MRI in the differential diagnosis of a sellar mass. Clin Radiol 58:20–31PubMedCrossRefGoogle Scholar
  7. 7.
    Desai MP, Mehta RU, Choksi CS (1996) Pituitary enlargement on magnetic resonance imaging in congenital hypothyroidism. Arch Pediatr Adolesc Med 150:623–628PubMedGoogle Scholar
  8. 8.
    Osborne AG (2004) Pituitary macroadenoma. In: Osborn AG (eds) Diagnostic imaging: brain. Amirsys, Salt Lake City, pp II-2–24Google Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Ki Seong Eom
    • 1
  • Choi See-Sung
    • 2
  • Jong Duck Kim
    • 3
  • Jong Moon Kim
    • 1
  • Tae Young Kim
    • 1
  1. 1.Department of NeurosurgeryWonkwang University School of MedicineIksanKorea
  2. 2.Department of RadiologyWonkwang University School of MedicineIksanKorea
  3. 3.Department of PediatricsWonkwang University School of MedicineIksanKorea

Personalised recommendations