We report a case of primary multifocal osseous lymphoma in a 6-year-old girl presenting with multifocal osteolytic lesions without systemic symptoms or identifiable non-osseous primary tumor. The differential diagnoses for such a presentation include histiocytosis X, chronic recurrent multifocal osteomyelitis, acute lymphoblastic leukemia, metastatic disease, and primary bone lymphoma. Although non-Hodgkin lymphoma is common in the pediatric population, its presentation as a primary bone tumor, especially with multifocal disease, is extremely rare and is frequently misdiagnosed. We hope that awareness of this entity will help radiologists achieve timely diagnosis and intervention.
Lymphoma Osseous Precursor B-cell Non-Hodgkin
This is a preview of subscription content, log in to check access.
Furman WL, Fitch S, Hustu HO et al (1989) Primary lymphoma of bone in children. J Clin Oncol 7:1275–1280PubMedGoogle Scholar
Glotzbecker MP, Kersun LS, Choi JK et al (2006) Primary non-Hodgkin’s lymphoma of bone in children. J Bone Joint Surg Am 88:583–594PubMedCrossRefGoogle Scholar
Melamed JW, Martinez S, Hoffman CJ (1997) Imaging of primary multifocal osseous lymphoma. Skeletal Radiol 26:35–41PubMedCrossRefGoogle Scholar
Iravani S, Singleton TP, Ross CW et al (1999) Precursor B lymphoblastic lymphoma presenting as lytic bone lesions. Am J Clin Pathol 112:836–843PubMedGoogle Scholar
Ozdemirli M, Fanburg-Smith JC, Hartmann DP et al (1998) Precursor B-lymphoblastic lymphoma presenting as a solitary bone tumor and mimicking Ewing’s sarcoma: a report of four cases and review of the literature. Am J Surg Pathol 22:795–804PubMedCrossRefGoogle Scholar
Krishnan A, Shirkhoda A, Tehranzadeh J et al (2003) Primary bone lymphoma: radiographic-MR imaging correlation. Radiographics 23:1371–1383PubMedCrossRefGoogle Scholar
Maitra A, McKenna RW, Weinberg AG et al (2001) Precursor B-cell lymphoblastic lymphoma. A study of nine cases lacking blood and bone marrow involvement and review of the literature. Am J Clin Pathol 115:868–875PubMedCrossRefGoogle Scholar
Lin P, Jones D, Dorfman DM et al (2000) Precursor B-cell lymphoblastic lymphoma: a predominantly extranodal tumor with low propensity for leukemic involvement. Am J Surg Pathol 24:1480–1490PubMedCrossRefGoogle Scholar