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Pediatric Radiology

, Volume 38, Issue 6, pp 694–696 | Cite as

Thickening and enhancement of multiple cranial nerves in conjunction with cystic white matter lesions in early infantile Krabbe disease

  • Lauren A. BeslowEmail author
  • Erin S. Schwartz
  • Carsten G. Bönnemann
Case Report

Abstract

We present serial MR findings in a child ultimately diagnosed with the early infantile form of Krabbe disease. MR showed typical features of Krabbe disease including cerebellar and brainstem hyperintensity, periventricular and deep white matter hyperintensity, and cerebral atrophy. In addition, the combination of both enlargement and enhancement of multiple cranial nerves in conjunction with unusual cystic lesions adjacent to the frontal horns of the lateral ventricles was previously unreported and expands the spectrum of imaging findings in early Krabbe disease.

Keywords

Krabbe disease Cranial nerve enlargement Cranial nerve enhancement Cystic lesions 

References

  1. 1.
    Escolar ML, Poe MD, Provenzale JM et al (2005) Transplantation of umbilical-cord blood in babies with infantile Krabbe’s disease. N Engl J Med 352:2069–2081PubMedCrossRefGoogle Scholar
  2. 2.
    Sasaki M, Sakuragawa N, Takashima S et al (1991) MRI and CT findings in Krabbe disease. Pediatr Neurol 7:283–288PubMedCrossRefGoogle Scholar
  3. 3.
    Jones BV, Barron TF, Towfighi J (1999) Optic nerve enlargement in Krabbe’s disease. AJNR 20:1228–1231PubMedGoogle Scholar
  4. 4.
    Nagar VA, Ursekar MA, Krishnan P et al (2006) Krabbe disease: unusual MRI findings. Pediatr Radiol 36:61–64PubMedCrossRefGoogle Scholar
  5. 5.
    Bernal OG, Lenn N (2000) Multiple cranial nerve enhancement in early infantile Krabbe’s disease. Neurology 54:2348–2349PubMedGoogle Scholar
  6. 6.
    Hittmair K, Wimberger D, Wiesbauer P et al (1994) Early infantile form of Krabbe disease with optic hypertrophy: serial MR examinations and autopsy correlation. AJNR 15:1454–1458PubMedGoogle Scholar
  7. 7.
    Vasconcellos E, Smith M (1998) MRI nerve root enhancement in Krabbe disease. Pediatr Neurol 19:151–152PubMedCrossRefGoogle Scholar
  8. 8.
    Suzuki K (2003) Globoid cell leukodystrophy (Krabbe’s disease): update. J Child Neurol 18:595–603PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Lauren A. Beslow
    • 1
    Email author
  • Erin S. Schwartz
    • 2
  • Carsten G. Bönnemann
    • 1
  1. 1.Division of NeurologyThe Children’s Hospital of PhiladelphiaPhiladelphiaUSA
  2. 2.Division of NeuroradiologyThe Children’s Hospital of PhiladelphiaPhiladelphiaUSA

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