Age-related findings on MRI in neurofibromatosis type 1
- 402 Downloads
T2 hyperintensities (T2H) on MRI are the most common CNS lesions in individuals with neurofibromatosis type 1 (NF1).
The aim was to determine the frequency, signal characteristics and localization of T2H at different ages. In addition, we examined the sensitivity of different MR imaging sequences in detecting these lesions.
Materials and methods
We studied prospectively a cohort of children, adolescents and young adults with NF1 using T2-volume (T2-V) and conventional MRI sequences. Lesions were designated as either discrete or diffuse, and the region of signal abnormality was recorded. A total of 103 patients were studied (age range 8.0–25.4 years, mean 13.9 years).
The frequency, size, and intensity of T2H decreased with age in the basal ganglia (BG) and the cerebellum/brainstem (CB/BS). The majority of thalamic and CB/BS lesions were diffuse. Of the total cohort, 80% had diffuse bilateral hippocampal hyperintensities and 18.4% had hemispheric lesions best demonstrated on FLAIR; there was no significant difference in the frequency or signal intensity of hemispheric lesions with age.
Lesions in the cerebral hemispheres and hippocampus imaged by MR do not change in prevalence over time, suggesting a different pathological basis from the lesions in the in BG and CB/BS that resolve with age. FLAIR and T2-V sequences are more sensitive in detecting lesions than standard T2-weighted sequences.
KeywordsNeurofibromatosis type 1 MRI Hippocampus
This research was supported by the Department of Defense Neurofibromatosis Research Program, managed by the U.S. Army Medical Research and Materiel Command (USAMRMC; award number DAMD17-00-1-0534). We are grateful to Dr. Sridhar Gibikote for his helpful comments on the significance of the radiological findings and Mrs. Susanne Smith for her administrative support.
- 7.North K, Ratner N (2003) The brain in neurofibromatosis type 1. In: Fisch GS (ed) Genetics and genomics of neurobehavioural disorders in contemporary clinical neurosciences series. Humana Press, Totowa, pp 97–135Google Scholar
- 10.Sevick RJ, Barkovich AJ, Edwards MSB, et al (1992) Evolution of white matter lesions in neurofibromatosis type 1: MR findings. AJNR 159:171–175Google Scholar