Liver involvement in Langerhans cell histiocytosis (LCH) typically presents with hepatomegaly and other signs of liver dysfunction. We present an 11-month-old child having only minimally elevated liver enzymes as an indication of liver involvement. Using sonography as the initial diagnostic tool followed by MRI, LCH of the liver was revealed. A review of sonographic, CT, MRI and MR cholangiopancreatography findings in liver LCH is presented. We recommend that physicians consider sonography and MRI screening for liver involvement in patients with newly diagnosed LCH, as periportal involvement may be present with little or no liver function abnormality present, as in this patient.
Langerhans cell histiocytosis Liver involvement Children Ultrasound CT MRI·MRCP
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We would like to thank Dr. Matthew Butcher, Martin Sherriff and Meg McIvor for their assistance in this case report.
The French Langerhans’ Cell Histiocytosis Study Group (1996) A multicentre retrospective survey of Langerhans’ cell histiocytosis: 348 cases observed between 1983 and 1993. Arch Dis Child 75:17–24CrossRefGoogle Scholar
Jaffe R (2004) Liver involvement in the histiocytic disorders of childhood. Pediatr Dev 7:214–225Google Scholar
Kilborn TN, Teh J, Goodman TR (2003) Paediatric manifestations of Langerhans cell histiocytosis: a review of the clinical and radiological findings. Clin Radiol 58:269–278PubMedCrossRefGoogle Scholar
Schmidt S, Eich G, Hanquinet S, et al (2004) Extra–osseous involvement of Langerhans’ cell histiocytosis in children. Pediatr Radiol 34:313–321PubMedCrossRefGoogle Scholar
Konig CW, Pfannenberg C, Trubenbach J, et al (2001) MR cholangiography in the diagnosis of sclerosing cholangitis in Langerhans’ cell histiocytosis. Eur Radiol 11:2516–2520PubMedCrossRefGoogle Scholar
Kim M, Lyu C, Jin Y, et al (1999) Langerhans’ cell histiocytosis as a cause of periportal abnormal signal intensity on MRI. Abdom Imaging 24:373–377PubMedCrossRefGoogle Scholar