Pediatric Radiology

, Volume 36, Issue 6, pp 561–563 | Cite as

Calcified pulmonary thromboembolism in a child with sickle cell disease: value of multidetector CT in patients with acute chest syndrome

  • Jonathan A. Staser
  • Tariq Alam
  • Kimberly Applegate
Case Report


The incidence of pulmonary embolism in children is not clearly known, but is believed to be low. Risk factors for pulmonary thromboembolism include central venous catheter, malignancy, surgery, infection, trauma, and congenital hypercoagulable disorders. Children with sickle cell disease are prothrombotic and are at an increased risk of thromboembolism. The incidence of this event is unknown because these children are often not thoroughly imaged. We report here a case of a calcified pulmonary thromboembolism in a child with sickle cell disease and emphasize the use of multidetector CT in detection of pulmonary thromboembolism in children with sickle cell disease.


Sickle cell disease Children Pulmonary embolism CT angiography 


  1. 1.
    Minter KR, Gladwin MT (2001) Pulmonary complications of sickle cell anemia: a need for increased recognition, treatment, and research. Am J Respir Crit Care Med 164:2016–2019PubMedGoogle Scholar
  2. 2.
    Vichinsky EP, Neumayr LD (2000) Causes and outcomes of the acute chest syndrome in sickle cell disease. N Engl J Med 342:1855–1865PubMedCrossRefGoogle Scholar
  3. 3.
    Babyn PS, Gahunia HK, Massicotte P, et al (2005) Pulmonary thromboembolism in children. Pediatr Radiol 35:258–274PubMedCrossRefGoogle Scholar
  4. 4.
    Johnson AS, Bolte RG (2004) Pulmonary embolism in the pediatric patient. Pediatr Emerg Care 20:555–563PubMedCrossRefGoogle Scholar
  5. 5.
    Chan AK, Deveber G, Monagle P, et al (2003) Venous thrombosis in children. J Thromb Haemost 1:1443–1455PubMedCrossRefGoogle Scholar
  6. 6.
    Andrew M, David M, Adams M, et al (1994) Venous thromboembolic complications (VTE) in children: first analyses of the Canadian Registry of VTE. Blood 83:1251–1257PubMedGoogle Scholar
  7. 7.
    Hayashino Y, Goto M, Noguchi Y, et al (2005) Ventilation-perfusion scanning and helical CT in suspected pulmonary embolism: meta-analysis of diagnostic performance. Radiology 234:740–748PubMedCrossRefGoogle Scholar
  8. 8.
    Patel S, Kazerooni E (2005) Helical CT for the evaluation of acute pulmonary embolism. AJR 185:135–149PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Jonathan A. Staser
    • 1
  • Tariq Alam
    • 2
  • Kimberly Applegate
    • 3
    • 4
  1. 1.Department of RadiologyIndiana University Medical CenterIndianapolisUSA
  2. 2.Department of RadiologyMedical College of OhioToledoUSA
  3. 3.Sections of Pediatric Radiology and Health Services ResearchIndiana University Medical CenterIndianapolisUSA
  4. 4.Department of Radiology, Riley Hospital for ChildrenIndiana University Medical CenterIndianapolisUSA

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