Potential Value of Native T1 Mapping in Symptomatic Adults with Congenital Heart Disease: A Preliminary Study of 3.0 Tesla Cardiac Magnetic Resonance Imaging

  • Yumi Shiina
  • Kei Inai
  • Kota Taniguchi
  • Tatsunori Takahashi
  • Michinobu NagaoEmail author
Original Article


The native T1 value at 3.0 Tesla is a sensitive marker of diffuse myocardial damage. We evaluated the clinical usefulness of native T1 mapping in symptomatic adults with congenital heart disease (CHD), particularly in the systemic right ventricle (RV). Prospectively, 45 consecutive symptomatic adults with CHD were enrolled: 20 with systemic RV and 25 with tetralogy of Fallot underwent cardiac magnetic resonance (CMR) imaging at 3.0 Tesla. The Modified Look-Locker Inversion recovery sequence was used for T1 mapping. Cardiovascular events in the systemic RV were defined as heart failure and tachyarrhythmia. Brain natriuretic peptide (BNP) and indexed systemic ventricular end-diastolic volume were significantly higher in the systemic RV group. The native T1 value and extracellular volume (ECV) of the septal and lateral walls were higher in the systemic RV group, suggesting high impairment of the myocardium in the systemic RV group. There was a strong correlation between the native T1 value and ECV of the septum (r = 0.58, P = 0.03) and lateral wall (r = 0.56, P = 0.046) in the systemic RV group. Seven patients with systemic RV had cardiovascular events. In univariate logistic regression analysis, BNP and native T1 values of the insertion point were important for predicting cardiovascular events. The native T1 value at 3.0 Tesla may be a sensitive, contrast-free, and non-invasive adjunct marker of myocardial damage in CHD and predictive of cardiovascular events in the systemic RV.


T1 mapping Native T1 Congenital heart disease Systemic right ventricle 



Congenital heart disease


Late gadolinium enhancement


Cardiac magnetic resonance


Brain natriuretic peptide


Extracellular volume


Hypertrophic cardiomyopathy


Dilated cardiomyopathy


Right ventricle


Congenitally collected transposition of the great arteries


Transposition of the great arteries


Tetralogy of Fallot


Region of interest


Left ventricle


End-diastolic volume


Ejection fraction


Pulmonary arterial hypertension



We would like to thank Editage ( for English language editing.


The authors state that this work has not received any funding.

Compliance with Ehical Standards

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Ethical Approval

Institutional Review Board approval was obtained. Study subjects or cohorts overlap: No study subjects or cohorts have been previously reported. Methodology: Prospective diagnostic or prognostic study performed at one institution.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Yumi Shiina
    • 1
    • 2
  • Kei Inai
    • 1
  • Kota Taniguchi
    • 1
  • Tatsunori Takahashi
    • 1
  • Michinobu Nagao
    • 3
    Email author
  1. 1.Department of Pediatric Cardiology and Adult Congenital CardiologyTokyo Women’s Medical UniversityTokyoJapan
  2. 2.Cardiovascular CenterSt. Luke’s International HospitalTokyoJapan
  3. 3.Department of Diagnostic Imaging & Nuclear MedicineTokyo Women’s Medical UniversityTokyoJapan

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