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In Utero Aortic Arch Thrombosis Masquerading as Interrupted Aortic Arch: A Case Report and Review of the Literature

  • Joseph J. KnadlerEmail author
  • Mark Zobeck
  • Prakash Masand
  • Sarah Sartain
  • William B. Kyle
Case Report

Abstract

Aortic arch thrombosis is an extremely rare but life-threatening diagnosis that is often misdiagnosed in the neonatal period. Strategies including surgical intervention, systemic anticoagulation, and thrombolysis have been previously described in the treatment of these neonates. We describe the case of a neonate who presented with concern for interrupted aortic arch and was diagnosed with an in utero aortic arch thrombosis. To our knowledge, this is the first reported case with evidence of aortic arch thrombosis in fetal life. The patient underwent successful treatment with systemic thrombolysis with tissue plasminogen activator. A brief review of the literature regarding the diagnosis, treatment, and management of neonatal aortic arch thrombosis is also presented.

Keywords

Aortic arch thrombosis Systemic thrombolysis Neonatal Thrombosis 

Notes

Acknowledgements

The authors would like to thank Anna Venardos, MD, Scott Osborne, MD, and Aimee Liou, MD for their help in the preparation of this manuscript.

Funding

This study received no funding.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Lillie Frank Abercrombie Section of Cardiology, Department of Pediatrics, Texas Children’s HospitalBaylor College of MedicineHoustonUSA
  2. 2.Section of Hematology, Department of Pediatrics, Texas Children’s HospitalBaylor College of MedicineHoustonUSA
  3. 3.Section of Radiology, Department of Pediatrics, Texas Children’s HospitalBaylor College of MedicineHoustonUSA

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