Advertisement

Pediatric Cardiology

, Volume 40, Issue 1, pp 177–181 | Cite as

Relationship Between Serum B7-H3 Levels and Prognosis of Congenital Heart Disease in Children

  • Rufang ZhangEmail author
  • Jin Gong
  • Shouqing Wang
  • Li Shen
  • Yewei Xie
  • Xiaobing Li
Original Article

Abstract

The aim of this study was to investigate the role of B7-H3 in prognosis of congenital heart disease (CHD) children patients. A total of 65 CHD patients within age 3–12 years who went to our hospital were included during August 2011 to December 2012. Demographic data including age, sex, weight, clinical basic information such as New York Heart Association (NYHA) class, pathological type were collected. Blood samples were collected and serum levels of B7-H3, C-reactive protein (CRP), N-Terminal Pro-Brain Natriuretic Peptide (NT-pro-BNP), and High-sensitivity Troponin T (hsTnT) were determined by enzyme-linked immunosorbent assay (ELISA). Characteristics including age, gender, weight, pathological type, NYHA class, and serum levels of hsTnT and CRP showed no significant difference between deceased and survival patients. However, serum levels of B7-H3 and NT-pro-BNP were significantly higher in deceased patients compared survival patients. Patients with high expressed B7-H3 had higher risks for total major cardiovascular events (MACE) occurrence compared with the lower group. Among the MACE events, significant difference was observed in rates of death, new onset of arrhythmias, and surgical, but not in NYHA class worsening and percutaneous intervention. Patients with higher levels if B7-H3 had significantly higher risk for mortality in the 5-year follow-up compared with the lower group, logic analysis was also conducted and results showed that B7-H3 might be an independent risk factor for 5-year mortality for CHD patients. B7-H3 was up-regulated in dead CHD patients, and serum levels of B7-H3 were related to long-term MACE and 5-year mortality of CHD patients.

Keywords

B7-H3 Congenital heart disease Prognosis Children 

Notes

Compliance with Ethical Standards

Conflict of interest

All authors declare they have no conflicts of interest.

Ethics Approval

Our manuscript complies with the Ethical Rules applicable for this journal. The ethic approval was obtained from the Ethic Committee of the Shanghai Children’s Hospital, and was in accordance with the Helsinki Declaration.

Informed Consent

All participants have signed the informed consent form before the study.

References

  1. 1.
    Warburton D, Ronemus M, Kline J, Jobanputra V, Williams I, Anyane-Yeboa K, Chung W, Yu L, Wong N, Awad D (2014) The contribution of de novo and rare inherited copy number changes to congenital heart disease in an unselected sample of children with conotruncal defects or hypoplastic left heart disease. Hum Genet 133(1):11–27.  https://doi.org/10.1007/s00439-013-1353-9 CrossRefGoogle Scholar
  2. 2.
    Marelli AJ, Ionescu-Ittu R, Mackie AS, Guo L, Dendukuri N, Kaouache M (2013) Lifetime prevalence of congenital heart disease in the general population from 2000 to 2010. J Am Coll Cardiol 61(10):749–756.  https://doi.org/10.1161/CIRCULATIONAHA.113.008396 CrossRefGoogle Scholar
  3. 3.
    Pan W, Wang Y, Lin L, Zhou G, Hua X, Mo L (2016) Outcomes of dexmedetomidine treatment in pediatric patients undergoing congenital heart disease surgery: a meta-analysis. Paediatr Anaesth 26(3):239–248.  https://doi.org/10.1111/pan.12820 CrossRefGoogle Scholar
  4. 4.
    Mussatto KA, Hoffmann RG, Hoffman GM, Tweddell JS, Bear L, Cao Y, Brosig C (2014) Risk and prevalence of developmental delay in young children with congenital heart disease. Pediatrics 133(3):e570.  https://doi.org/10.1542/peds.2013-2309 CrossRefGoogle Scholar
  5. 5.
    Mussatto KA, Hoffmann R, Hoffman G, Tweddell JS, Bear L, Cao Y, Tanem J, Brosig C (2015) Risk factors for abnormal developmental trajectories in young children with congenital heart disease. Circulation 132(8):755.  https://doi.org/10.1161/CIRCULATIONAHA CrossRefGoogle Scholar
  6. 6.
    Glatz AC, Purrington KS, Klinger A, King AR, Hellinger J, Zhu X, Gruber SB, Gruber PJ (2014) Cumulative exposure to medical radiation for children requiring surgery for congenital heart disease. J Pediatr 164(4):789–794.  https://doi.org/10.1016/j.jpeds CrossRefGoogle Scholar
  7. 7.
    Zomer AC, Verheugt CL, Vaartjes I, Uiterwaal CS, Langemeijer MM, Koolbergen DR, Hazekamp MG, van Melle JP, Konings TC, Bellersen L (2011) Surgery in adults with congenital heart disease. Circulation 124(20):2195.  https://doi.org/10.1161/CIRCULATIONAHA CrossRefGoogle Scholar
  8. 8.
    Ohuchi H, Diller GP (2014) Biomarkers in adult congenital heart disease heart failure. Heart Fail Clin 10(1):43–56CrossRefGoogle Scholar
  9. 9.
    Makimura M, Koga H (2014) N-terminal pro-brain natriuretic peptide as a useful predictor of early surgery in neonates with congenital heart diseases: a prospective observational study. Pediatr Cardiol 35(1):77–81.  https://doi.org/10.1007/s00246-013-0744-y CrossRefGoogle Scholar
  10. 10.
    Eindhoven JA, Roos-Hesselink JW, Bosch AEVD, Kardys I, Cheng JM, Veenis JF, Cuypers JAAE, Witsenburg M, Schaik RHNV, Boersma E (2015) High-sensitive troponin-T in adult congenital heart disease. Int J Cardiol 184(1):405–411.  https://doi.org/10.1016/j.ijcard.2015.02.027 CrossRefGoogle Scholar
  11. 11.
    Daniels LB, Barrett-Connor E, Clopton P, Laughlin GA, Ix JH, Maisel AS (2012) Plasma neutrophil gelatinase-associated lipocalin is independently associated with cardiovascular disease and mortality in community-dwelling older adults: The Rancho Bernardo Study. J Am Coll Cardiol 59(12):1101–1109.  https://doi.org/10.1016/j.jacc.2011.11.046 CrossRefGoogle Scholar
  12. 12.
    Chen C, Shen Y, Qu QX, Chen XQ, Zhang XG, Huang JA (2013) Induced expression of B7-H3 on the lung cancer cells and macrophages suppresses T-cell mediating anti-tumor immune response. Exp Cell Res 319(1):96–102.  https://doi.org/10.1016/j.yexcr.2012.09.006 CrossRefGoogle Scholar
  13. 13.
    Boland JM, Kwon ED, Harrington SM, Wampfler JA, Tang H, Yang P, Aubry MC (2013) Tumor B7-H1 and B7-H3 expression in squamous cell carcinoma of the lung. Clin Lung Cancer 14(2):157–163.  https://doi.org/10.1016/j.cllc.2012.05.006 CrossRefGoogle Scholar
  14. 14.
    Yan L, Yuan Q, Jie H, Yi PL, Jian P, Xing F, Xue GZ, Jiang HW, Jian W (2016) Assessment of plasma B7-H3 levels in pediatric patients with different degrees of surgical stress. BMC Pediatr 16(1):110.  https://doi.org/10.1186/s12887-016-0655-1 CrossRefGoogle Scholar
  15. 15.
    Lin EY, Cohen HW, Bhatt AB, Stefanescu A, Dudzinski D, Defaria YD, Johnson J, Lui GK (2015) Predicting outcomes using the heart failure survival score in adults with moderate or complex congenital heart disease. Congenit Heart Dis 10(5):387–395.  https://doi.org/10.1111/chd.12229 CrossRefGoogle Scholar
  16. 16.
    Van Der Bom T, Zomer AC, Zwinderman AH, Meijboom FJ, Bouma BJ, Mulder BJ (2011) The changing epidemiology of congenital heart disease. Nat Rev Cardiol 8(1):50–60.  https://doi.org/10.1038/nrcardio.2010.166 CrossRefGoogle Scholar
  17. 17.
    Zomer AC, Vaartjes I, Et VDV, de Jong HM, Konings TC, Wagenaar LJ, Heesen WF, Eerens F, Baur LH, Grobbee DE (2013) Heart failure admissions in adults with congenital heart disease; risk factors and prognosis. Int J Cardiol 168(3):2487–2493.  https://doi.org/10.1016/j.ijcard.2013.03.003 CrossRefGoogle Scholar
  18. 18.
    Nir A, Luchner A, Rein AJ (2012) The natriuretic peptides as biomarkers for adults with congenital heart disease. Biomark Med 6(6):827–837.  https://doi.org/10.2217/bmm.12.73 CrossRefGoogle Scholar
  19. 19.
    Blok IM, van Riel AC, Schuuring MJ, de Bruin-Bon RH, van Dijk AP, Hoendermis ES, Zwinderman AH, Mulder BJ, Bouma BJ (2016) The role of cystatin C as a biomarker for prognosis in pulmonary arterial hypertension due to congenital heart disease. Int J Cardiol 209:242–247.  https://doi.org/10.1016/j.ijcard.2016.02.003 CrossRefGoogle Scholar
  20. 20.
    Frogoudaki A, Andreou C, Parissis J, Maniotis C, Nikolaou M, Rizos I, Filippatos G, Lekakis J (2014) Clinical and prognostic implications of plasma NGAL and NT-proBNP in adult patients with congenital heart disease. Int J Cardiol 177(3):1026–1030.  https://doi.org/10.1016/j.ijcard.2014.09.134 CrossRefGoogle Scholar
  21. 21.
    Schuuring MJ, van Riel AC, Vis JC, Duffels MG, van Dijk AP, de Bruin-Bon RH, Zwinderman AH, Mulder BJ, Bouma BJ (2015) New predictors of mortality in adults with congenital heart disease and pulmonary hypertension: midterm outcome of a prospective study. Int J Cardiol 181:270–276.  https://doi.org/10.1016/j.ijcard.2014.11.222 CrossRefGoogle Scholar
  22. 22.
    Schuuring MJ, van Riel AC, Vis JC, Duffels MG, van Straalen JP, Boekholdt SM, Tijssen JG, Mulder BJ, Bouma BJ (2013) High-sensitivity troponin T is associated with poor outcome in adults with pulmonary arterial hypertension due to congenital heart disease. Congenit Heart Dis 8(6):520–526.  https://doi.org/10.1111/chd.12022 CrossRefGoogle Scholar
  23. 23.
    Arigami T, Uenosono Y, Hirata M, Yanagita S, Ishigami S, Natsugoe S (2011) B7-H3 expression in gastric cancer: a novel molecular blood marker for detecting circulating tumor cells. Cancer Sci 102(5):1019–1024.  https://doi.org/10.1111/j.1349-7006.2011.01877.x CrossRefGoogle Scholar
  24. 24.
    Liu C, Liu J, Wang J, Liu Y, Zhang F, Lin W, Gao A, Sun M, Wang Y, Sun Y (2013) B7-H3 expression in ductal and lobular breast cancer and its association with IL-10. Mol Med Rep 7(1):134.  https://doi.org/10.3892/mmr.2012.1158 CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Rufang Zhang
    • 1
    Email author
  • Jin Gong
    • 1
  • Shouqing Wang
    • 2
  • Li Shen
    • 1
  • Yewei Xie
    • 1
  • Xiaobing Li
    • 1
  1. 1.Department of Cardiothoracic Surgery, Shanghai Children’s HospitalShanghai Jiao Tong UniversityShanghaiChina
  2. 2.Department of SurgeryHuai’an City Women and Children’s HospitalHuai’anChina

Personalised recommendations