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Serum Resistin Negatively Correlates with Clinical Severity of Postural Tachycardia Syndrome in Children

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Abstract

This study was designed to analyse the serum resistin level in children with postural tachycardia syndrome (POTS) and its clinical significance. Twenty-one children with POTS and 31 healthy children as controls participated in the study. Clinical characteristics, heart rate and blood pressure in the supine and upright positions were monitored and collected during an upright test, and the symptom scoring of POTS patients was recorded. The serum resistin levels of patients in both groups were determined by enzyme-linked immunosorbent assay. The change in serum resistin levels in the POTS group before and after standing, as well as its correlation with symptom scores and change in heart rate after standing, was analysed. Compared with the control group, the serum resistin levels in the POTS group were significantly increased (P < 0.01). The serum resistin levels in the POTS group before and after standing did not differ (P > 0.05). There was a negative correlation between the serum resistin levels and a change in heart rate from the supine to upright position (correlation coefficient = −0.615, P < 0.01). Moreover, serum resistin levels were negatively correlated with symptom scores (correlation coefficient = −0.493, P < 0.05). Serum resistin levels in children with POTS were significantly higher than those in healthy children and negatively correlated with a change in heart rate from the supine to upright position and symptom scores. These results suggest a protective role of increased resistin in the pathogenesis of POTS.

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Author notes

  1. Wei Bai and Zhenhui Han have contributed equally to this work.

Authors and Affiliations

  1. Department of Pediatrics, Peking University First Hospital, No. 1, Xi’an-men Street, West District, Beijing, 100034, People’s Republic of China

    Wei Bai, Hongxia Li, Jingyuan Song, Jianguang Qi, Ying Liao, Ping Liu, Yuli Wang, Hongfang Jin & Junbao Du

  2. Department of Medical and Educational Administration, Children’s Hospital of Kaifeng, Kaifeng, Henan Province, People’s Republic of China

    Zhenhui Han

  3. Department of the Intensive Care Unit of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, People’s Republic of China

    Siyao Chen

  4. Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, 100191, People’s Republic of China

    Chaoshu Tang

  5. Key Laboratory of Molecular Cardiology, Ministry of Education, Beijing, 100191, People’s Republic of China

    Chaoshu Tang

Authors
  1. Wei Bai
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  2. Zhenhui Han
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  4. Hongxia Li
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  8. Chaoshu Tang
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  9. Ping Liu
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  10. Yuli Wang
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  11. Hongfang Jin
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  12. Junbao Du
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Corresponding author

Correspondence to Hongfang Jin.

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Conflict of interest

All authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all participants in this study in the form of written consent from parents and written assent from children.

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Bai, W., Han, Z., Chen, S. et al. Serum Resistin Negatively Correlates with Clinical Severity of Postural Tachycardia Syndrome in Children. Pediatr Cardiol 38, 1639–1644 (2017). https://doi.org/10.1007/s00246-017-1708-4

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  • DOI: https://doi.org/10.1007/s00246-017-1708-4

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