Interventional VSD-Closure with the Nit-Occlud® Lê VSD-Coil in 110 Patients: Early and Midterm Results of the EUREVECO-Registry
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In August 2010, the Nit-Occlud® Lê (EUREVECO) became available for transcatheter coil occlusion of ventricular septal defects (VSDs). Retrospective European Registry for VSD Closure using the Nit-Occlud® Lê-VSD-Coil; analysis of the feasibility, results, safety and follow-up of VSD-closure over a 3-year period in 18 European centers. In 102 of 111 patients (female 66), successful VSD closure was performed (mean age 8.2 years, mean weight 28.82 kg), 81 perimembranous VSDs (48 with aneurysm), 30 muscular VSDs, mean procedure time was 121.1 min, and mean fluoroscopy time was 26.3 min. Short- and midterm term follow-up was possible in 100/102 patients, there was 1 embolization and 1 explantation after 24 months. Immediate complete closure occurred in 49 of 101 patients (48.5%), trivial residual shunt was present in 51 (50.0%), closure rate was 95% after 6 months and 97% after 1 year. Out of the 102 patients, there were 2 severe complications (1.8%) (1 severe hemolysis, 1 embolization) and 8 moderate/transient (=7.2%) including 1 transient AV block. During a mean follow-up period of 31.3 months (range 24–48) and a total follow-up time of 224.75 patient years, no further problems occurred. VSD closure with the Nit-Occlud® Lê VSD coil is feasible and safe with a minimal risk of severe side effects. The long-term effects and safety require further clinical follow-up studies.
KeywordsInterventional VSD closure Perimembranous VSD Muscular VSD Congenital heart defects Nit-Occlud® Lê-VSD-Coil EUREVECO
Ventricular septum defect
- Nit-Occlud® Lê-VSD-Coil
Coil used in this study
European Registry for Ventricular Septal Defect Coil Occlusion
Right bundle branch block
- AVBlock III°
Third-degree complete atrioventricular block
The funding is by hospital funding only.
Compliance with ethical standards
Conflict of interest
There is no conflict of interest by any of the authors regarding this report.
- 3.Yang J, Yang L, Yu S, Liu J, Zuo J, Chen W, Duan W, Zheng Q, Xu X, Li J, Zhang J, Xu J, Sun L, Yang X, Xiong L, Yi D, Wang L, Liu Q, Ge S, Ren J (2014) Transcatheter versus surgical closure of perimembranous ventricular septal defects in children: a randomized controlled trial. J Am Coll Cardiol 63(12):1159–1168CrossRefPubMedGoogle Scholar
- 6.Carminati M, Butera G, Chessa M, De Giovanni J, Fisher G, Gewillig M, Peuster M, Piechaud JF, Santoro G, Sievert H, Spadoni I, Walsh K, Investigators of the European VSD Registry (2007) Transcatheter closure of congenital VSDs: results of the European Registry. Eur Heart J 28:2361–2368CrossRefPubMedGoogle Scholar
- 23.Koneti NR, Verma S, Bakhru S, Vadlamudi K, Kahtare P, Penumatsa RR, Qureshi S (2013) Transcatheter trans-septal antegrade closure of muscular VSD in young children. Cath Cardiovasc Interv 82(4):E500–E506Google Scholar
- 30.Li X, Li L, Wang X, Zhao H-B, Zhang S-Y (2011) Clinical analysis of transcatheter closure of perimembranous VSD with occluders made in China. Chin Med J 2011(124):2117–2122Google Scholar