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Pediatric Cardiology

, Volume 34, Issue 8, pp 2089–2092 | Cite as

Severe Constrictive Pericarditis After Parvovirus B19 and Human Herpes Virus 6 Infection in a 9-Year-Old Girl

  • David BackhoffEmail author
  • Michael Steinmetz
  • Wolfgang Ruschewski
  • Barbara Stastny
  • Reinhard Kandolf
  • Ulrich Krause
Case Report

Abstract

We report on a 9-year-old girl who developed signs of congestive heart failure with significant ascites due to constrictive pericarditis. Cardiac catheterization was performed to establish the diagnosis and to rule out restrictive cardiomyopathy. Endomyocardial biopsies were positive for activated macrophages and small-vessel disease, but no viral genomes were detected. Open pericardectomy was performed and histopathologic examination of the resected thickened pericardium showed extensive fibrosis and hyaline degeneration. A combined infection with parvovirus B19 (PVB19) and human herpes virus 6 (HHV6; subtype B) was proven within the resected pericardium. We suggest that local HHV6-induced immunosuppression enhanced the PVB19 infection, thus resulting in chronic infection and leading to constrictive pericarditis.

Keywords

Constrictive pericarditis Parvovirus B19 Human herpes virus 6 Child Heart failure Pericardectomy 

Abbreviations

PVB19

Parvovirus B19

HHV6

human Herpes virus 6

Notes

Conflict of interest

The authors have no conflicts of interest to disclose.

Supplementary material

Supplementary material 1 (MPG 450 kb)

Supplementary material 2 (MPG 102 kb)

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • David Backhoff
    • 1
    Email author
  • Michael Steinmetz
    • 1
  • Wolfgang Ruschewski
    • 2
  • Barbara Stastny
    • 3
  • Reinhard Kandolf
    • 4
  • Ulrich Krause
    • 1
  1. 1.Department of Pediatric Cardiology and Intensive Care Medicine, Georg-August-University Hospital GöttingenUniversity of GöttingenGöttingenGermany
  2. 2.Department of Thoracic Cardiovascular Surgery, Georg-August-University Hospital GöttingenUniversity of GöttingenGöttingenGermany
  3. 3.Department of PediatricsKassel School of MedicineKasselGermany
  4. 4.Department of Molecular Pathology, University Hospital of TübingenUniversity of TübingenTübingenGermany

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