Pediatric Cardiology

, Volume 34, Issue 8, pp 2030–2033

Fetal Right-Ventricular Hypertrophy With Pericardial Effusion and Maternal Untreated Hyperthyroidism

  • Elena N. Kwon
  • Mamatha Kambalapalli
  • Gary Francis
  • Mary T. Donofrio
Case Report

DOI: 10.1007/s00246-012-0580-5

Cite this article as:
Kwon, E.N., Kambalapalli, M., Francis, G. et al. Pediatr Cardiol (2013) 34: 2030. doi:10.1007/s00246-012-0580-5


Uncontrolled/untreated maternal hyperthyroidism has been associated with fetal tachycardia. We report a case of right-ventricular (RV) hypertrophy with pericardial effusion related to untreated maternal Graves’ disease. A 33-year-old G4P1021 woman with uncontrolled Graves’ disease presented at 29 weeks gestation with abdominal pain and vaginal bleeding. Fetal echocardiogram showed severe RV hypertrophy and a pericardial effusion. The infant was born prematurely, and initial transthoracic echocardiogram showed severe RV hypertrophy and a small pericardial effusion. The infant had clinical findings consistent with congenital thyrotoxicosis and was treated for this. Follow-up imaging at 4 weeks showed improvement of the cardiac hypertrophy and pericardial effusion. This article describes the presentation of fetal RV hypertrophy with congenital thyrotoxicosis and underscores the importance of screening for this prenatally in mothers with uncontrolled or untreated hyperthyroidism.


Fetal cardiomyopathy Maternal hyperthyroidism Pregnancy Congenital thyrotoxicosis 

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Elena N. Kwon
    • 1
    • 2
    • 5
  • Mamatha Kambalapalli
    • 3
  • Gary Francis
    • 3
  • Mary T. Donofrio
    • 4
  1. 1.Division of Cardiology, Department of PediatricsVirginia Commonwealth UniversityRichmondUSA
  2. 2.Division of Maternal Fetal Medicine, Department of Obstetrics and GynecologyVirginia Commonwealth UniversityRichmondUSA
  3. 3.Division of Endocrinology and Metabolism, Department of PediatricsVirginia Commonwealth UniversityRichmondUSA
  4. 4.Division of Cardiology, Department of PediatricsChildren’s National Medical CenterWashingtonUSA
  5. 5.Division of Pediatric CardiologyChildren’s Hospital of RichmondRichmondUSA

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