Polymorphism 677C→T MTHFR Gene in Mexican Mothers of Children With Complex Congenital Heart Disease
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Congenital heart defects (CHD) are the third leading cause of death in children <1 year of age in Mexico where there is a high prevalence of the 677C→T polymorphism of the MTHFR gene. This is important because the homozygous 677T/T MTHFR gene and deficiency of folic acid (FA) intake have been associated with CHD. Our objective was to analyze the possible association between the genotype 677T/T of the MTHFR gene and supplementation of FA in Mexican women with the presence of complex CHD in their children. We analyzed genotypes of 31 mothers of children with complex CHD (group I) and 62 mothers of healthy children (group II) and investigated FA supplementation during pregnancy in both study groups. Allele frequencies in group I were 41.9 % for C and 58.1 % for T and 22.6 % for genotype frequencies CC, 38.7 % for CT, and 38.7 % for TT. Allele frequencies in group II were 63.7 % for C and 36.3 % for T and 38.7 % for genotype frequencies CC, 50 % for CT and 11.3 % for TT. Both populations are in Hardy–Weinberg equilibrium. Odds ratio for having a child with a complex CHD was 5.9, p = 0.008 (95 % CI 1.67; 20.63) for the TT genotype. FA supplementation at any time during pregnancy was 90.3 and 87.9 % in groups II and I respectively (p > 0.05). Association was found between the maternal genotype (677/TT MTHFR) with the presence of complex CHD in their offspring. No differences in FA supplementation during any stage were found between groups.
KeywordsMTHFR gene 677→T polymorphism Congenital heart disease Folic acid
We are grateful to the authorities of the Research Directive of Hospital Infantil de México Federico Gómez for help in carrying out this study. This project was performed under the auspices of the Federal Fund program (2009) from the Ministry of Health, México.
- 9.Dirección General de Información en Salud, Secretaria de Salud (2005) Mortalidad preescolar. Bol Med Hosp Infant Mex 62:69–82Google Scholar
- 20.Kueh K, Loffredo C, Lammer EJ, Iovannisci DM, Shaw GM (2010) Association of congenital cardiovascular malformations with 33 single nucleotide. Birth Defects Res A Clin Mol Teratol 88:101–110Google Scholar