Pediatric Cardiology

, Volume 32, Issue 4, pp 455–460

The Functions of Endothelial Progenitor Cells Were Significantly Improved After Treatment With Intravenous Immunoglobulin and Aspirin in Children With Kawasaki Disease

  • Ming Guo Xu
  • Li Na Men
  • Ying Zu
  • Chun Yu Zhao
  • Xiang Chun Meng
  • Tao Wang
Original Article

DOI: 10.1007/s00246-011-9900-4

Cite this article as:
Xu, M.G., Men, L.N., Zu, Y. et al. Pediatr Cardiol (2011) 32: 455. doi:10.1007/s00246-011-9900-4

Abstract

We sought to determine the effects of treatment with intravenous immunoglobulin (IVIG) and aspirin on the functions of endothelial progenitor cells (EPCs) in patients with Kawasaki disease (KD) as well as its relationship with concentrations of tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP). Ten KD patients in the acute phase of their disease were recruited. We investigated EPC functions in children with KD before and after treatment with IVIG and aspirin. In vitro assays were used to measure the functions, including proliferation, adhesion, and migration activities, of EPCs. Plasma levels of TNF-α and hs-CRP were also assessed. All of the data were assessed before and at 7 days after treatment initiation. EPC functions after 7 days of treatment with IVIG and aspirin were significantly improved than they were before treatment with IVIG and aspirin. Treatment with IVIG and aspirin significantly decreased TNF-α and hs-CRP concentrations. There was a significant linear regression relationship between decreased plasma TNF-α levels, hs-CRP levels, and increased functions of circulating EPCs. The results of our study indicate that the functions of circulating EPCs improved after treatment with IVIG and aspirin, which may be related to decreased concentrations of TNF-α and hs-CRP.

Keywords

Kawasaki disease Intravenous immunoglobulin Endothelial progenitor cell 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Ming Guo Xu
    • 1
  • Li Na Men
    • 2
  • Ying Zu
    • 3
  • Chun Yu Zhao
    • 1
  • Xiang Chun Meng
    • 1
  • Tao Wang
    • 1
  1. 1.The Cardiovascular CenterShen-Zhen Children’s HospitalShen-ZhenChina
  2. 2.The Neurology DepartmentShen-Zhen Children’s HospitalShen-ZhenChina
  3. 3.The Pediatric Research InstituteShen-Zhen Children’s HospitalShen-ZhenChina

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