Pediatric Cardiology

, Volume 32, Issue 1, pp 84–86 | Cite as

Parvovirus-Mediated Fetal Cardiomyopathy With Atrioventricular Nodal Disease

  • Shira G. FishmanEmail author
  • Linda M. Pelaez
  • Rebecca N. Baergen
  • Sheila J. Carroll
Case Report


Acute parvovirus B19 infection (API) in pregnancy has been associated with fetal anemia and hydrops fetalis. Direct myocardial damage from API in a fetus and an infant has been described. This report presents a case of fetal second-degree heart block and cardiomyopathy secondary to API. A 19-year-old G4P1112 (gravida 4 para 2 with 1 term delivery, 1 preterm delivery, 1 termination, and 2 living children) was referred at 20 weeks gestation for fetal bradycardia. A 2:1 atrioventricular block was identified by fetal echocardiography at 23 weeks. Hydrops developed at 25 weeks. Amniocentesis and percutaneous umbilical blood sampling demonstrated API. At 31 weeks, the patient presented with preterm labor and delivered a viable female infant, who died of poor cardiac function and arrhythmia on the first day of life. In addition to fetal anemia and hydrops fetalis, API in pregnancy may cause direct fetal myocardial damage and conduction system disease.


Atrioventricular nodal disease Fetal cardiomyopathy Fetal digoxin Parvovirus B19 

Supplementary material

Movie clip 1 Short-axis view showing bilateral ventriculomegaly, decreased cardiac function, and dyskinetic septal motion. (MOV 1622 kb)

Movie clip 2 Four-chamber view with moderate to severe mitral and tricuspid insufficiency and decreased cardiac function. (MOV 1803 kb)


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Shira G. Fishman
    • 1
    Email author
  • Linda M. Pelaez
    • 1
  • Rebecca N. Baergen
    • 2
  • Sheila J. Carroll
    • 3
  1. 1.Division of Maternal Fetal Medicine, Department of Obstetrics and GynecologyWeill Medical College of Cornell UniversityNew YorkUSA
  2. 2.Division of Obstetric and Perinatal Pathology, Department of Pathology and Laboratory MedicineWeill Medical College of Cornell UniversityNew YorkUSA
  3. 3.Division of Pediatric Cardiology, Department of PediatricsWeill Medical College of Cornell UniversityNew YorkUSA

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