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Pediatric Cardiology

, Volume 30, Issue 7, pp 965–970 | Cite as

Preserved Flow-Mediated Dilation in Adults with Cyanotic Congenital Heart Disease

  • Christian M. PedersenEmail author
  • Michael R. Schmidt
  • Bente Mortensen
  • Hussain Contractor
  • Hans Erik Bøtker
  • Rajesh K. Kharbanda
  • Keld E. Sørensen
Original Article

Abstract

Adults with cyanotic congenital heart disease (CCHD) have been shown to have endothelial dysfunction in the forearm resistance vessels as assessed with venous occlusion plethysmography. Whether these abnormalities are confined to the microvasculature or reflect generalized endothelial dysfunction remain unknown. We used high-resolution ultrasound to compare flow responses and endothelial-dependent flow-mediated dilation (FMD) in the brachial artery of 13 adult patients with CCHD and 14 healthy controls. High-dose vitamin C was infused to evaluate the possible role of reactive oxygen species on endothelial vasomotor function. FMD was measured both prior to and after vitamin C infusion. Sublingual glyceryl nitrate was given to assess endothelium-independent responses. FMD did not differ among patients with CCHD and controls either before (6.2 ± 4.1, 5.1 ± 2.6%, p = 0.44) or after (5.1 ± 2.8, 5.2 ± 3.1%, p = 0.90) vitamin C infusion. Endothelium-independent vasodilatation was similar in both groups (14.3 ± 3.7, 13.2 ± 4.4%). There were no differences in baseline flow or in measures of reactive hyperemia. Adults with CCHD appear to have preserved endothelial function in their conduit arteries. This suggests that these patients are not at an increased risk of premature atherosclerotic cardiovascular events.

Keywords

Endothelium Congenital heart disease Cyanosis Vitamin C 

Notes

Acknowledgments

Funded by Fondation Leducq and NIHR Biomedical Research Centre Programme.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Christian M. Pedersen
    • 1
    Email author
  • Michael R. Schmidt
    • 1
  • Bente Mortensen
    • 1
  • Hussain Contractor
    • 2
  • Hans Erik Bøtker
    • 1
  • Rajesh K. Kharbanda
    • 2
  • Keld E. Sørensen
    • 1
  1. 1.Department of CardiologyAarhus University Hospital SkejbyAarhus NDenmark
  2. 2.Department of Cardiovascular MedicineThe John Radcliffe HospitalHeadington, OxfordUK

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