Pediatric Cardiology

, Volume 30, Issue 5, pp 626–634 | Cite as

Analysis of Ventricular Hypertrabeculation and Noncompaction Using Genetically Engineered Mouse Models

  • Hanying Chen
  • Wenjun Zhang
  • Deqiang Li
  • Tim M. Cordes
  • R. Mark Payne
  • Weinian ShouEmail author
Riley Symposium


Ventricular trabeculation and compaction are two of the many essential steps for generating a functionally competent ventricular wall. A significant reduction in trabeculation is usually associated with ventricular compact zone deficiencies (hypoplastic wall), which commonly lead to embryonic heart failure and early embryonic lethality. In contrast, hypertrabeculation and lack of ventricular wall compaction (noncompaction) are closely related defects in cardiac embryogenesis associated with left ventricular noncompaction, a genetically heterogeneous disorder. Here we summarize our recent findings through the analyses of several genetically engineered mouse models that have defects in cardiac trabeculation and compaction. Our data indicate that cellular growth and differentiation signaling pathways are keys in these ventricular morphogenetic events.


Ventricular development Trabeculation and compaction Signaling 



This study was supported in part by National Institutes of Health Grants HL81092 (W.S.), HL70259 (W.S.), and HL85098 (W.S., M.P.).


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Hanying Chen
    • 1
  • Wenjun Zhang
    • 1
  • Deqiang Li
    • 1
  • Tim M. Cordes
    • 1
  • R. Mark Payne
    • 1
  • Weinian Shou
    • 1
    Email author
  1. 1.Riley Heart Research Center, Herman B. Wells Center for Pediatric Research, Department of PediatricsIndiana University School of MedicineIndianapolisUSA

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