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Pediatric Cardiology

, 30:46 | Cite as

Impaired Elastic Properties of the Ascending Aorta Persist Within the First 3 Years After Neonatal Coarctation Repair

  • Andreas Kühn
  • Daniela Baumgartner
  • Christian Baumgartner
  • Jürgen Hörer
  • Christian Schreiber
  • John Hess
  • Manfred VogtEmail author
Original Article

Abstract

Abnormal elastic properties of the ascending aorta in patients with coarctation of the aorta (CoA) are already present in neonates before and after successful repair. To prove the midterm outcome for vascular pathology, a cohort of 15 patients was prospectively reevaluated. In this study, 15 patients after neonatal CoA repair (study group) and 15 healthy normal children (control group) were examined (mean age, 3.0 ± 1.0 years). The aortic wall stiffness index and distensibility were calculated using ascending and abdominal aortic M-mode diameters and noninvasive estimation of pulse pressure. The study group was compared with the control group and with its own previously obtained pre- and postoperative measurements. After a mean follow-up period of 2.9 ± 0.9 years, the elastic properties of the ascending aorta remained impaired in the study group compared with the control group (distensibility: 62 ± 28 vs 94 ± 34; p = 0.01; stiffness index: 4.4 ± 1.9 vs 2.7 ± 1.0; p = 0.008). At follow-up evaluation, the elasticity of the ascending aorta in the study group showed no change from the initial neonatal findings (distensibility: 63 ± 24 vs 62 ± 28; p = 0.82; stiffness index: 4.0 ± 1.6 vs 4.4 ± 1.9; p = 0.65). In both groups, descending aortic elasticity increased during the follow-up period. Our data suggest that the diminished elastic properties of the prestenotic arteries remain unchanged years after successful CoA repair. Comparisons with the neonatal data showed no evidence for remodeling of the ascending aorta in this group.

Keywords

Coarctation Echocardiography Elasticity 

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Andreas Kühn
    • 1
  • Daniela Baumgartner
    • 2
  • Christian Baumgartner
    • 3
  • Jürgen Hörer
    • 4
  • Christian Schreiber
    • 4
  • John Hess
    • 1
  • Manfred Vogt
    • 1
    Email author
  1. 1.Department of Pediatric Cardiology and Congenital Heart DiseaseDeutsches Herzzentrum MünchenMünchenGermany
  2. 2.Clinical Division of Pediatric CardiologyInnsbruck Medical UniversityInnsbruckAustria
  3. 3.Research Group for Clinical BioinformaticsUniversity for Health Sciences, Medical Informatics, and TechnologyHallAustria
  4. 4.Department of Cardiovascular SurgeryDeutsches Herzzentrum MünchenMünchenGermany

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