Pediatric Cardiology

, Volume 29, Issue 4, pp 771–774

First Description of Three Patients with Multifocal Lymphangiomatosis and Protein-Losing Enteropathy Following Palliation of Complex Congenital Heart Disease with Total Cavo-Pulmonary Connection

  • M. Glöckler
  • T. Severin
  • R. Arnold
  • P. Greiner
  • K. O. Schwab
  • M. Uhl
  • C. Schlensak
  • J. Rössler
  • S. Dittrich
Original Article

Abstract

The objective was to identify abdominal lymphatic malformations in pediatric patients with protein-losing enteropathy after palliation of complex congenital heart disease with total cavo-pulmonary connection (TCPC). In 2006, we performed complete hemodynamic and laboratory workup and thoracic and abdominal MRT screens in three patients who newly presented with symptoms of protein-losing enteropathy. All three patients, aged 3, 5, and 7 years, showed excellent TCPC hemodynamics with central venous pressures of 10–13 mm Hg. None of the patients had right-to-left overflow. All three patients showed extensive thoracic and mesenterial lymphangiomatosis. One patient died after 18 months of therapy, which included long-term parenteral nutrition, somatostatin, subcutaneous heparin injections, and frequent albumin and immunoglobulin substitution. The other two patients are in stable condition. Lymphangiomatosis might play an unknown role in the pathogenesis of protein-losing enteropathy after TCPC. It remains unclear whether lymphangiomatosis is a primary congenital disease related to the cardiac disease or if it is triggered by repeated surgery or venous congestion. The presence of lymphangiomatosis should be given diagnostic and therapeutic consideration in TCPC patients in the future.

Keywords

Lymphangiomatosis Total cavo-pulmonary connection Protein-losing enteropathy 

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • M. Glöckler
    • 1
  • T. Severin
    • 1
  • R. Arnold
    • 1
  • P. Greiner
    • 2
  • K. O. Schwab
    • 2
  • M. Uhl
    • 3
  • C. Schlensak
    • 4
  • J. Rössler
    • 5
  • S. Dittrich
    • 1
  1. 1.Department of Pediatric CardiologyUniversity Medical Center FreiburgFreiburgGermany
  2. 2.Department of PediatricsUniversity Medical Center FreiburgFreiburgGermany
  3. 3.Department of Pediatric RadiologyUniversity Medical Center FreiburgFreiburgGermany
  4. 4.Department of Cardiovascular SurgeryUniversity Medical Center FreiburgFreiburgGermany
  5. 5.Department of Pediatric OncologyUniversity Medical Center FreiburgFreiburgGermany

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