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Pediatric Cardiology

, Volume 26, Issue 6, pp 866–868 | Cite as

Asystole during Outbursts of Laughing in a Child with Angelman Syndrome

  • W.Y. VanagtEmail author
  • C.F. Pulles-Heintzberger
  • K. Vernooy
  • R.N. Cornelussen
  • T. Delhaas
Article

Abstract

A girl with Angelman syndrome had recurrent episodes of ventricular asystole and syncope caused by severe vagal hypertonia during outbursts of laughing. After intravenous administration of atropine, laughing no longer induced asystole or syncope. The vast majority of patients with Angelman syndrome have seizures. Since hypoxia associated with asystole can provoke convulsions, we suggest electrocardiographic evaluation of Angelman patients with symptomatic bradycardia, loss of consciousness, or convulsions related to laughing.

Keywords

Angelman Asystole Bradycardia Vagal hypertonia 

References

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • W.Y. Vanagt
    • 1
    • 2
    Email author
  • C.F. Pulles-Heintzberger
    • 1
  • K. Vernooy
    • 2
    • 3
  • R.N. Cornelussen
    • 2
  • T. Delhaas
    • 1
    • 2
  1. 1.Department of Pediatrics, Division of Pediatric CardiologyUniversity Hospital MaastrichtMaastrichtThe Netherlands
  2. 2.Department of PhysiologyMaastricht UniversityMaastrichtThe Netherlands
  3. 3.Department of CardiologyUniversity Hospital MaastrichtMaastrichtThe Netherlands

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