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Pediatric Cardiology

, Volume 25, Issue 3, pp 191–200 | Cite as

Cardiovascular Embryology

  • R. AbdullaEmail author
  • G. A. Blew
  • M. J. Holterman
Article

Abstract

During the first 20 days of development, the human embryo has no cardiovascular structure. Over the next month, the heart and great vessels complete their development and look very much like they will at full gestation. This amazing process transforms isolated angiogenic cell islets into a complex, four-chambered structure. During this transformation, the single heart tube begins to beat at 23 days of development and by 30 days blood circulates through the embryo.

Keywords

Heart Cardiovascular Embryology Primitive heart Heart looping Outflow tract septation 

Supplementary material

The heart borders are traced on each slide, and then stacked, using computer software, to re-construct the 3-D image of the embryo heart. This could be repeated at various embryological stages to witness the developmental changes of the heart.

The “flat embryo” folds along its long axis, thus giving the embryo its tubular shape. The lateral endocardial tubes come together, as a result of the folding, ventral to the embryo and fuse to form a single heart tube

The atrial septum is initially formed by the septum primum which grows towards the fused middle portion of the atrio-ventricular endocardial cushions. A fenestration appears within the septum primum, just before it completes its growth. A second septum, just right to the septum primum grows and covers the fenestration, but continue to allow communication between the two atria (patent foramen ovale).

The heart is viewed from the back. Normal development of systemic venous return is shown. Note that the connection between the left innominant vein and the left sinus horn degenerates.

The heart is viewed from the back. Abnormal development of systemic venous return is shown. Note that the connection between the left innominant vein and the left sinus horn persists. This results in the formation of a left superior vena cava, draining to the coronary sinus.

References

  1. 1.
    Abdulla, R 2000The three dimensional heart.Pediatr Cardiol21409CrossRefPubMedGoogle Scholar
  2. 2.
    Anderson, RH 1986Description of ventricular septal defect—or how long is a piece of string?Int J Cardiol13267278CrossRefPubMedGoogle Scholar
  3. 3.
    Anderson, RH 1991Simplifying the understanding of congenital malformation of the heart.Int J Cardiol32131142CrossRefPubMedGoogle Scholar
  4. 4.
    Anderson, RH, Wilkinson, JL, Rosenquist, GC, Bergsma, D 1978The bulbus cordis.Morphogenesis and Malformation of the Cardiovascular System.LissNew York128Google Scholar
  5. 5.
    Anderson, PAW 1995The molecular genetics of cardiovascular disease.Curr Opin Cardiol103343PubMedGoogle Scholar
  6. 6.
    Bartelings, MM 1989The outflow tract of the heart—embryologic and morphologic correlations.Int J Cardiol22289300CrossRefPubMedGoogle Scholar
  7. 7.
    Bartelings, MM 1990The Outflow Tract of the Heart - embryologic and morphholayre correlations. Fnt. J Condcol22289300Google Scholar
  8. 8.
    Bartelings, MM, Gittenberger-deGroot, AC 1988The arterial orifice level in the early human embryo.Anat Embryol177537542PubMedGoogle Scholar
  9. 9.
    Bartelings, MM,  et al. 1986Contribution of the aortopulmonary septum to the muscular outlet septum in the human heart.Acta Morphol Neerl-Scand24181192PubMedGoogle Scholar
  10. 10.
    Becker, AE, Anderson, RH 1984Cardiac embryology.Nora, JJTalao, A eds. Congenital Heart Disease: Causes and Processes.FuturaNew York339358Google Scholar
  11. 11.
    Benson, DW,  et al. 1996New understanding in the genetics of congenital heart disease.Curr Opin Pediatr8505511PubMedGoogle Scholar
  12. 12.
    Bockman, ED 1987Effect of neural crest on the development of the heart and arch arteries in the chick.Am J Anat180332341PubMedGoogle Scholar
  13. 13.
    Bolender, D, Holterman, ML 2001Animated thoughts on teaching human development.FASEB J15Abstract 793.1Google Scholar
  14. 14.
    Burn, J, Goodship, J 1996Developmental genetics of the heart.Curr Opin Genet Dev6322326CrossRefPubMedGoogle Scholar
  15. 15.
    Clark, EB 1984Hemodynamic control of the chick embryo cardiovascular system.Nora, JJTalao, A eds. Congenital Heart Disease: Causes and Processes.FuturaNew York337386Google Scholar
  16. 16.
    Colvin, EV 1998Cardiac embryology.Garson, A Jr eds. The Science and Practice of Pediatric Cardiology, 2nd edn.Williams & WilkinsBaltimore91126Google Scholar
  17. 17.
    Creazzo, TL,  et al. 1998Role of cardiac neural crest in cardiovascular development.Ann Rev Physiol60267286CrossRefGoogle Scholar
  18. 18.
    Hay, DA 1978Development and fusion of the endocardial cushion.Rosenquist, GCBergsma, D eds. Morphogenesis and Malformations of the Cardiovascular System.LissNew York6990Google Scholar
  19. 19.
    Holterman MJ, et al (1999) The Visible Embryo Project: new approaches to embryology education [abstract]. American Academy of Pediatrics Surgical section meeting, Washington DCGoogle Scholar
  20. 20.
    Holterman MJ, Blew G, Bolender D, Abdulla R (2001) Clinical education development using multimedia [abstract]. Biannual meeting of the American Association of Clinical Anatomists and the British Association of Clinical Anatomists, Cambridge, UKGoogle Scholar
  21. 21.
    Holterman, MJ, Oladapo, A, Abdulla, R 1999Clinically relevant embryology: new approach to education [abstract].American Academy of PediatricsWashington, DCGoogle Scholar
  22. 22.
    Kathiriya, IS, Srivastava, D 2000Left–right asymmetry and cardiac looping: implications for cardiac development and congenital heart disease.Am J Med Genet97271279CrossRefPubMedGoogle Scholar
  23. 23.
    Kirby, ML 1989Plasticity and predetermination of mesencephalic and trunk neural crest transplanted into the region of the cardiac neural crest.Dev Biol134402412PubMedGoogle Scholar
  24. 24.
    Kirby, ML, Waldo, KL 1990Role of neural crest in congenital heart disease.Circulation82232340Google Scholar
  25. 25.
    Larsen, WJ 1997aHuman Embryology, 2nd edn.Churchill LivingstoneNew York4961Google Scholar
  26. 26.
    Larsen, WJ 1997bHuman Embryology, 2nd edn.Churchill LivingstoneNew York151188Google Scholar
  27. 27.
    Los, JA 1978Cardiac septation and development of the aorta, pulmonary trunk, and pulmonary veins.Rosenquist, GCBergsma, D eds. Morphogenesis and Malformations of the Cardiovascular System.LissNew York109138Google Scholar
  28. 28.
    McBride, RE 1981Development of the outflow tract and closure of the interventricular septum.Am J Anat106309331Google Scholar
  29. 29.
    McGowan Jr, FX 1992Cardiovascular and airway interactions.Int Anesthesiol Clin302144PubMedGoogle Scholar
  30. 30.
    Moorman, AF, de Jong, F, Denyn, MM,  et al. 1998Development of the cardiac conduction system.Circ Res82629644PubMedGoogle Scholar
  31. 31.
    Morse, DE 1978Scanning electron microscopy of the developing septa in the chick heart.Rosenquist, GCBergsma, D eds. Morphogenesis and Malformations of the Cardiovascular System.LissNew York91107Google Scholar
  32. 32.
    Nadal-Ginard, B, Mahdavi, V 1993Basic mechanism of cardiac gene expression.Eur Heart J14211Google Scholar
  33. 33.
    Nora, J, Berg, K, Nora, AH 1991Cardiovascular Disease: Genetics, Epidemiology and Prevention.Oxford University PressNew YorkGoogle Scholar
  34. 34.
    Olson, EN, Srivastava, D 1996Molecular pathways controlling heart development.Science272671675PubMedGoogle Scholar
  35. 35.
    Pensky, B 1982Review of Medical Embryology.McMillanNew York291355Google Scholar
  36. 36.
    Pexieder, T 1978Development of the outflow tract of the embryonic heart.Rosenquist, GCBergsma, D eds. Morphogenesis and Malformation of the Cardiovascular System.LissNew York2968Google Scholar
  37. 37.
    Pexieder, T, Janecek, P 1984Organogenesis of the human embryonic and early fetal heart as studied by microdissection and SEM.Nora, JJTalao, A eds. Congenital Heart Disease: Causes and Processes.FuturaNew York401422Google Scholar
  38. 38.
    Srivastava, D 2001Genetic assembly of the heart: implications for congenital heart disease.Annu Rev Physiol63451469CrossRefPubMedGoogle Scholar
  39. 39.
    Steding, G, Seidl, W 1984Cardiac septation in normal development.Nora, JJTalao, A eds. Congenital Heart Disease: Causes and Processes.FuturaNew York481500Google Scholar
  40. 40.
    Thompson, RP 1985Morphogenesis of human cardiac outflow.Anat Rec213578586PubMedGoogle Scholar
  41. 41.
    Van Mierop, LHS 1979Morphological development of the heart.Berne, RM eds. Handbook of Physiology, the Cardiovascular System.American Physiology SocietyBethesda, MD128Google Scholar
  42. 42.
    Van Mierop, LHS 1986Cardiovascular anomalies in DiGeorge syndrome and importance of neural crest as a possible pathogenetic factor.Am J Cardiol58133137CrossRefPubMedGoogle Scholar
  43. 43.
    Wenink, ACG 1986Embryology of the mitral valve.Int J Cardiol117584CrossRefPubMedGoogle Scholar
  44. 44.
    Wenink, ACG, Gittenberger-deGroot, AC 1985The role of atrioventricular endocardial cushion in the septation of the heart.Int J Cardiol82544CrossRefPubMedGoogle Scholar
  45. 45.
    Whiten, S, Smart, SD, McLachlan, JC, Aiton, JF 1998Computer-aided interactive three-dimensional reconstruction of the embryonic human heart.J Anat193337345CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Pediatric CardiologyThe University of Chicago. MC4051, 5841 S. Maryland Ave., Chicago, IL 60637-1470USA
  2. 2.School of Biomedical VisualizationUniversity of Illinois at Chicago, 840 S. Wood Street, Chicago, IL 60637 USA
  3. 3.Department of SurgeryUniversity of Illinois at Chicago, 840 S. Wood Street, Chicago, IL 60637USA

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