Advertisement

Pediatric Cardiology

, Volume 24, Issue 2, pp 127–132 | Cite as

Increased Angiogenic Growth Factor in Cyanotic Congenital Heart Disease

  • W. Himeno
  • T. Akagi
  • J. Furui
  • Y. Maeno
  • M. Ishii
  • K. Kosai
  • T. Murohara
  • H. Kato

To examine the relationship between the plasma levels of angiogenic growth factors and the severity of cyanosis, 80 patients with cyanotic heart disease (CHD) and 81 healthy controls were studied. Median age and mean arterial blood oxygen saturation respectively were 4.2 years and 81% in CHD subjects and 4.8 years and 98% in controls. Vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) were measured in plasma using enzyme-linked immunoassay. Plasma VEGF levels in controls depended negatively on age (p < 0.0001) until 3 months, when VEGF was no longer elevated. No such age dependence was found for HGF. Although VEGF levels did not differ between CHD and control subjects up to the age of 3 months, VEGF was significantly elevated in CHD patients older than 3 months compared to controls of similar age (149 ± 106 vs 65 ± 23 pg/ml, p < 0.0001). Moreover, the VEGF levels were negatively correlated with oxygen saturation (p = 0.03) and positively correlated with hemoglobin (p = 0.004) in CHD patients aged between 3 months and 10 years. Although the physiologic elevation of VEGF in the neonatal period decreases rapidly if oxygen saturation is normal, VEGF elevations persist if systemic hypoxia is present.

Keywords

Vascular Endothelial Growth Factor Congenital Heart Disease Oxygen Saturation Hepatocyte Growth Factor Blood Oxygen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag New York Inc. 2003

Authors and Affiliations

  • W. Himeno
    • 1
  • T. Akagi
    • 1
  • J. Furui
    • 1
  • Y. Maeno
    • 1
  • M. Ishii
    • 1
  • K. Kosai
    • 2
  • T. Murohara
    • 3
  • H. Kato
    • 1
  1. 1.Department of Pediatrics, Kurume University, 67 Asahi-machi, Kurume, Japan 830-0011JP
  2. 2.Research Center for Innovative Cancer Therapy, Kurume University, 67 Asahi-machi, Kurume, Japan 830-0011JP
  3. 3.Institute of Cardiovascular Disease, Kurume University, 67 Asahi-machi, Kurume, Japan 830-0011JP

Personalised recommendations