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Occurrence, Seasonal Variation and Risk Assessment of Antibiotics in the Surface Water of North China

  • Jiaxing Cheng
  • Lei Jiang
  • Tangqiang Sun
  • Yan Tang
  • Zhenxia DuEmail author
  • Lingjun LeeEmail author
  • Qiyue Zhao
Article

Abstract

In this study, the occurrence, seasonal, and spatial variations of four classes antibiotics were investigated in the surface water of North China. Water samples were taken from 24 sampling sites along rivers in May and August and antibiotics in water samples were detected by SPE-UPLC-MS/MS. The occurrence of all antibiotics except for FLO in May were higher than in August. The mean concentrations of four classes antibiotics detected in May and August were in the following order respectively: quinolones (421.23 ng/L) > tetracyclines (28.37 ng/L) > amphenicols (20.38 ng/L) > sulfonamides (5.79 ng/L) and amphenicols (284.36 ng/L) > quinolones (15.74 ng/L) > tetracyclines (3.05 ng/L) > sulfonamides (0.20 ng/L). The results showed that quinolones and amphenicols were dominant antibiotics among four classes antibiotics. To explore the source of antibiotics from the fish ponds nearby, antibiotic concentration data, which was investigated in the sediment, fish feed and fish revealed a direct relationship between the main antibiotics and fish farms along the rivers. Risk assessment data indicated enrofloxacin and florfenicol could cause higher safety risks to aquatic organisms compared to other antibiotics.

Notes

Acknowledgements

This work was funded by the Fundamental Research Funds for the Central Universities (ZZ1706). The author thanks the Beijing Municipal Environmental Monitoring Center for its help in collecting water samples.

Compliance with Ethical Standards

Conflict of interest

The authors declared that they have no conflict of interest.

Supplementary material

244_2019_605_MOESM1_ESM.docx (56 kb)
Supplementary material 1 (DOCX 55 kb)

References

  1. Anthony AA, Adekunle CF, Thor AS (2018) Residual antibiotics, antibiotic resistant superbugs and antibiotic resistance genes in surface water catchments: public health impact. Phys Chem Earth 105:177–183CrossRefGoogle Scholar
  2. Batt AL, Snow DD, Aga DS (2006) Occurrence of sulfonamide antimicrobials in private water wells in Washington County, Idaho, USA. Chemosphere 64:1963–1971CrossRefGoogle Scholar
  3. Bielen A, Šimatović A, Kosićvukšić J, Senta I, Ahel M, Babić S, Jurina T, González PJJ, Milaković M, Udiković-Kolić N (2017) Negative environmental impacts of antibiotic-contaminated effluents from pharmaceutical industries. Water Res 126:79–87CrossRefGoogle Scholar
  4. Campagnolo ER, Johnson KR, Karpati A, Rubin CS, Kolpin D, Meyer MT, Esteban JE, Currier RW, Smith K, Thu KM, McGeehin M (2002) Antimicrobial residues in animal waste and water resources proximal to large-scale swine and poultry feeding operations. Sci Total Environ 299(1):89–95CrossRefGoogle Scholar
  5. Chantziaras I, Boyen F, Callens B, Dewulf J (2013) Correlation between veterinary antimicrobial use and antimicrobial resistance in food-producing animals: a report on seven countries. J Antimicrobial Chemother 69(3):827–834CrossRefGoogle Scholar
  6. Chen K, Zhou JL (2014) Occurrence and behavior of antibiotics in water and sediments from the Huangpu River, Shanghai, China. Chemosphere 95(5):604–612CrossRefGoogle Scholar
  7. Chen H, Chen H, Ying J, Huang J, Liao L (2009) Dispersive liquid-liquid microextraction followed by high-performance liquid chromatography as an efficient and sensitive technique for simultaneous determination of chloramphenicol and thiamphenicol in honey. Anal Chim Acta 632(1):80–85CrossRefGoogle Scholar
  8. Chen H, Jing J, Teng Y, Wang J (2018) Characterization of antibiotics in a large-scale river system of China: occurrence pattern, spatiotemporal distribution and environmental risks. Sci Total Environ 618:409–418CrossRefGoogle Scholar
  9. Dionysiou DD, Suidan MT, Baudin I, Laı̂Né JM (2004) Effect of hydrogen peroxide on the destruction of organic contaminants-synergism and inhibition in a continuous-mode photocatalytic reactor. Appl Catal B Environ 50(4):259–269CrossRefGoogle Scholar
  10. González-Pleiter M, Gonzalo S, Rodea-Palomares I, Leganés F, Rosal R, Boltes K, Marco E, Fernández-Piñas F (2013) Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms: implications for environmental risk assessment. Water Res 47(6):2050–2064CrossRefGoogle Scholar
  11. Gros M, Petrovic M, Barcelo D (2006) Development of a multi-residue analytical methodology based on liquid chromatography–tandem mass spectrometry (LC–MS/MS) for screening and trace level determination of pharmaceuticals in surface and wastewaters. Talanta 70:678–690CrossRefGoogle Scholar
  12. Hernández F, Sancho JV, Ibáñez M, Guerrero C (2007) Antibiotic residue determination in environmental waters by LC–MS. Trac Trends Anal Chem 26(6):466–485CrossRefGoogle Scholar
  13. Hernando MD, Mezcua M, Fernandez-Alba AR, Barcelo D (2006) Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments. Talanta 69:334–342CrossRefGoogle Scholar
  14. Hu XG, Zhou QX, Luo Y (2010) Occurrence and source analysis of typical veterinary antibiotics in manure, soil, vegetables and groundwater from organic vegetable bases, northern China. Environ Pollut 158:2992–2998CrossRefGoogle Scholar
  15. Jiang L, Hu X, Yin D, Zhang H, Yu Z (2011) Occurrence, distribution and seasonal variation of antibiotics in the Huangpu River, Shanghai, China. Chemosphere 82(6):822–828CrossRefGoogle Scholar
  16. Kehrenberg C, Schwarz S (2006) Distribution of florfenicol resistance genes fexA and cfr among chloramphenicol-resistant Staphylococcus isolates. Antimicrobial Agents Chemother 50(4):1156–1163CrossRefGoogle Scholar
  17. Lei T, Ping L, Wang YX, Zhu KZ (2009) Analysis of veterinary antibiotic residues in swine wastewater and environmental water samples using optimized SPE-LC/MS/MS. Chemosphere 74(8):1090–1097CrossRefGoogle Scholar
  18. Managaki S, Murate A, Takada H, Tuyen BX, Chiem NH (2007) Distribution of macrolides, sulfonamides, and trimethoprim in tropical waters: ubiquitous occurrence of veterinary antibiotics in the Mekong Delta. Environ Sci Technol 41:8004–8010CrossRefGoogle Scholar
  19. Martínez-Carballo E, González-Barreiro C, Scharf S, Gans O (2007) Environmental monitoring study of selected veterinary antibiotics in animal manure and soils in Austria. Environ Pollut 148:570–579CrossRefGoogle Scholar
  20. Matsui Y, Ozu T, Inoue T, Matsushita T (2008) Occurrence of a veterinary antibiotic in streams in a small catchment area with livestock farms. Desalination 226(1):215–221CrossRefGoogle Scholar
  21. Pena A, Pina J, Silva LJG, Meisel L, Lino CM (2010) Fluoroquinolone antibiotics determination in piggeries environmental waters. J Environ Monit 12(3):642–646CrossRefGoogle Scholar
  22. Sánchez-Bayo F, Baskaran S, Kennedy IR (2002) Ecological relative risk (EcoRR): another approach for risk assessment of pesticides in agriculture. Agric Ecosyst Environ 91(1–3):37–57CrossRefGoogle Scholar
  23. Sun J, Zeng Q, Dcw T, Li X (2017) Antibiotics in the agricultural soils from the Yangtze River Delta, China. Chemosphere 189:301–308CrossRefGoogle Scholar
  24. Tello A, Austin B, Telfer TC (2012) Selective pressure of antibiotic pollution on bacteria of importance to public health. Environ Health Persp 120:1100–1106CrossRefGoogle Scholar
  25. Thomaidi VS, Matsoukas C, Stasinakis AS (2017) Risk assessment of triclosan released from sewage treatment plants in European rivers using a combination of risk quotient methodology and Monte Carlo simulation. Sci Total Environ 603–604:487CrossRefGoogle Scholar
  26. Wang J, Leung D (2007) Analyses of macrolide antibiotic residues in eggs, raw milk, and honey using both ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry and high-performance liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 21(19):3213–3222CrossRefGoogle Scholar
  27. Wiuff C, Lykkesfeldt J, Aarestrup FM, Svendsen O (2002) Distribution of enrofloxacin in intestinal tissue and contents of healthy pigs after oral and intramuscular administrations. Vet Pharmacol Therap 25:335–342CrossRefGoogle Scholar
  28. Xu W, Zhang G, Li X, Zou S, Li P, Hu Z, Li J (2007) Occurrence and elimination of antibiotics at four sewage treatment plants in the Pearl River Delta (PRD), South China. Water Res 41(19):4526–4534CrossRefGoogle Scholar
  29. Yan C, Yang Y, Zhou J, Liu M, Nie M, Shi H, Gu L (2013) Antibiotics in the surface water of the Yangtze Estuary: occurrence, distribution and risk assessment. Environ Pollut 175:22–29CrossRefGoogle Scholar
  30. Yang JF, Ying GG, Zhao JL, Tao R, Su HC, Liu YS (2011) Spatial and seasonal distribution of selected antibiotics in surface waters of the Pearl Rivers, China. J Environ Sci Health Part B 46(3):272–280CrossRefGoogle Scholar
  31. Zhang R, Tang J, Li J, Zheng Q, Liu D, Chen Y, Zou Y, Chen X, Luo C, Zhang G (2013) Antibiotics in the offshore waters of the Bohai Sea and the Yellow Sea in China: occurrence, distribution and ecological risks. Environ Pollut 174(5):71–77CrossRefGoogle Scholar
  32. Zhang QQ, Ying GG, Pan CG, Liu YS, Zhao JL (2015) Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance. Environ Sci Technol 49:6772–6782CrossRefGoogle Scholar
  33. Zou S, Xu W, Zhang R, Tang J, Chen Y, Zhang G (2011) Occurrence and distribution of antibiotics in coastal water of the Bohai Bay, China: impacts of river discharge and aquaculture activities. Environ Pollut 159(10):2913–2920CrossRefGoogle Scholar

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Faculty of ScienceBeijing University of Chemical TechnologyBeijingChina
  2. 2.Beijing Municipal Environmental Monitoring CenterBeijingChina

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