Uptake and Elimination of Chlorpyrifos and Pentachlorophenol into the Freshwater Amphipod Gammarus pulex
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Uptake and elimination rates were determined for chlorpyrifos (CPF) and pentachlorophenol (PCP) in the freshwater amphipod Gammarus pulex. Internal concentrations of the two pesticides were measured over a three-day exposure phase and a subsequent three-day elimination phase. Rate constants were obtained by fitting measured internal concentrations to a one-compartment single first-order model. The uptake rate constants were 747 ± 61 [L kg−1 day−1] for CPF and 89 ± 7 [L kg−1 day−1] for PCP. The elimination rate constants were 0.45 ± 0.05 [day−1] for CPF and 1.76 ± 0.14 [day−1] for PCP. The resulting bioconcentration factors at steady state were 1660 and 51 for CPF and PCP, respectively. The parameter estimation method and possible variability due to varying lipid content are briefly discussed.
KeywordsLipid Content Elimination Rate Chlorpyrifos Leaf Material Elimination Rate Constant
This work was funded under the EU framework VI programme, project number SSPE-CT-2003-501997 (HAIR: Harmonised environmental Indicators for Pesticide Risk).
- Crane M, Maltby L (1991) The lethal and sublethal responses of Gammarus pulex to stress: sensitivity and sources of variation in an in situ bioassay. Environ Toxicol Chem 10:1331–1339Google Scholar
- Gobas FAPC, Morrison HA (2000) Bioconcentration and biomagnification in the Aquatic Environment. In: Boethling RS, Mackay D, (eds), Handbook of property estimation methods for chemicals. CRC Press, Boca Raton 189–231Google Scholar
- Handy RD (1994) Intermittent exposure to aquatic pollutants: assessment, toxicity and sublethal responses in fish and invertebrates. Comp Biochem Phys C 107(2):171–184Google Scholar
- Kooijman SALM, Bedaux JJM (1996) The analysis of aquatic toxicity data. VU University Press, Amsterdam, NetherlandsGoogle Scholar
- Landrum PF, Dupuis WS (1990) Toxicity and toxicokinetics of pentachlorophenol and carbaryl to Pontoporeia hoyi and Mysis relicta. In: Landis WG, van der Schalie WH (eds) Aquatic toxicology and risk assessment. Philadelphia: American Society for Testing and Materials, pp 278–289Google Scholar
- Landrum PF, Lee HI, Lydy MJ (1992) Toxicokinetics in aquatic systems: model comparisons and use in hazard assessment. Environ Toxicol Chem 11:1709–1725Google Scholar
- Modelkinetix (2000): Modelmaker reference. Cherwell Scientific Ltd., OxfordGoogle Scholar
- Roberts TR, Hutson DH, Jewess PJ, Lee PW, Nicholls PH, Plimmer JR (1999): Metabolic pathways of agrochemicals. Part 2: Insecticides and fungicides. The Royal Society of Chemistry, Cambridge, UKGoogle Scholar
- Tomlin CDS (2000) The pesticide manual, 12 ed. British Crop Protection Council Fornham, UKGoogle Scholar
- van Wijngaarden RPA, van den Brink PJ, Crum SJH, Oude Voshaar JH, Brock TCM, Leeuwangh P (1996) Effects of the insecticide Dursban 4E (active ingredient chlorpyrifos) in outdoor experimental ditches: I. Comparison of short-term toxicity between the laboratory and the field. Environ Toxicol Chem 15(7):1133–1142CrossRefGoogle Scholar