Selected Haematological and Biochemical Parameters of Blood in Rats After Subchronic Administration of Vanadium and/or Magnesium in Drinking Water

  • Agnieszka Ścibior
  • Halina Zaporowska
  • Jarosław Ostrowski
Article

DOI: 10.1007/s00244-005-0126-4

Cite this article as:
Ścibior, A., Zaporowska, H. & Ostrowski, J. Arch Environ Contam Toxicol (2006) 51: 287. doi:10.1007/s00244-005-0126-4

Abstract

The purpose of these studies was to evaluate the effect of selected vanadium and magnesium doses on certain haematological and biochemical blood parameters in rats. Outbred 2-month-old, albino male Wistar rats received for a period of 6 weeks, as a sole drinking liquid, the following water solutions: group II, sodium metavanadate (SMV) at a concentration of 0.125 mg V/mL; group III, magnesium sulphate (MS) at a concentration of 0.06 mg Mg/mL; and group IV, SMV-MS solution at the same concentrations. The control group received at this time deionized water to drink. It was calculated that group II ingested with drinking water about 10.7 mg V/kg b. w./24 h, group III 6 mg Mg/kg b. w./24 h, and group IV about 9 mg V and 4.5 mg Mg/kg b. w./24 h. The exposure to vanadium alone (group II) led to a statistically significant decrease in body weight gain, food and fluid intakes. Moreover, in the same group of rats a statistically significant decrease in the RBC count, Hb concentration, MCV, and MCH values was demonstrated. Additionally, a statistically significant decrease in the plasma L-ascorbic acid concentration and a significant increase in MDA concentration in blood in this group were found. Instead, after the administration of magnesium alone (group III), a statistically significant decrease in the fluid intake and in the L-ascorbic acid concentration in plasma was noted. Furthermore, in the same group of rats a statistically significant increase in Hb level and in the plasma magnesium concentration was demonstrated. Two-way analysis of variance (ANOVA) did not reveal the interactions between V and Mg.

Abbrevations

SMV

sodium metavanadate;

MS

magnesium sulphate;

SMV-MS

sodium metavanadate and magnesium sulphate;

AMV

ammonium metavanadate;

VS

vanadyl sulphate;

MDA

malondialdehyde;

TAS

total antioxidant status;

RBC

red blood cells;

WBC

white blood cells;

Hb

haemoglobin;

Ht

haematocrait;

MCV

mean corpuscular volume;

MCH

mean corpuscular haemoglobin;

MCHC

mean corpuscular haemoglobin concentration;

RDW

red cell distribution width;

ABTS

2,′ 2,′-azino-di-3-ethylbenzthiazoline sulphonate.

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Agnieszka Ścibior
    • 1
  • Halina Zaporowska
    • 1
  • Jarosław Ostrowski
    • 2
  1. 1.Department of Cell Biology, Institute of Environmental ProtectionJohn Paul II Catholic University of LublinLublinPoland
  2. 2.Voivodship Inspectorate of Environmental ProtectionLublinPoland

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