Biological Monitoring of Bisphenol A in a Korean Population

  • Mihi Yang
  • Soo-Young Kim
  • Su-Man Lee
  • Seong-Sil Chang
  • Toshihiro Kawamoto
  • Jae-Yeon Jang
  • Yoon-Ok Ahn

Abstract

To conduct proper biological monitoring of environmental exposure to bisphenol A (BPA), the variation in host susceptibility need to be investigated. For this purpose, we studied effects of genetic polymorphism in sulfotransferase (SULT) 1A1 on urinary BPA, a biomarker for BPA exposure, in 73 Koreans (male, 34; female, 39; age, 48.9 ± 11.9 yrs). We used reverse phase-HPLC/FD for analysis of urinary BPA and obtained information from each subject on lifestyle, environment, and potential exposure to BPA via food. The HPLC/FD method showed good reproducibility (CVs < 0.1) and a relatively sensitive detection limit of 0.012 μg/L. These methods yielded a geometric mean of urinary BPA as 9.54 μg/L (8.91 μg/g creatinine), with a geometric standard deviation of 8.32 μg/L. Among potential routes for BPA exposure, only “vinyl wrapping of microwave heating” indicated a borderline positive association with urinary BPA level (p = 0.1). After PCR-RFLP, we found the allele frequencies of SULT1A1*1 and SULT1A1*2 were 0.89 and 0.11, respectively within the subjects. As the SULT1A1*1 allele of SULT1A1 is known to be a rapid sulfonylation-allele, the presence of SULT1A1*1 is suspected to rapidly dispose of environmental BPA. However resultant, urinary BPA levels were not significantly different between the SULT1A1*1/*1 identified subjects and the SULT1A1*1/*2 subjects. Therefore, to clarify host variability in urinary BPA level, different genetic polymorphisms in BPA metabolic enzymes other than SULT1A1 should be further studied.

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Copyright information

© Springer-Verlag New York Inc. 2003

Authors and Affiliations

  • Mihi Yang
    • 1
  • Soo-Young Kim
    • 2
  • Su-Man Lee
    • 1
  • Seong-Sil Chang
    • 3
  • Toshihiro Kawamoto
    • 4
  • Jae-Yeon Jang
    • 5
  • Yoon-Ok Ahn
    • 1
  1. 1.Department of Preventive Medicine, Cancer Research Institute, College of Medicine, Seoul National University, 28 Yongon-Dong Chongno-Gu, Seoul, 110–799, KoreaKR
  2. 2.Department of Preventive Medicine, School of Medicine, Eulji University, 143-5 Yongdu-Dong, Chung-Gu, Dajeon, 301-112, KoreaKR
  3. 3.Department of Preventive Medicine and Public Health, College of Medicine, Chungnam National University, 220, Gung-Dong, Yuseong-Gu, Daejeon, 305-764, KoreaKR
  4. 4.Department of Environmental Health, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, JapanJP
  5. 5.Department of Preventive Medicine, Ajou University, San 5, Wonchun-Dong, Paldal-Gu, Suwon, 442-749, KoreaKR

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