A preliminary study: the role of preoperative procalcitonin in predicting postoperative fever after mini-percutaneous nephrolithotomy in patients with a negative baseline urine culture

  • Deng Li
  • Minglei Sha
  • Lei Chen
  • Yinglong Xiao
  • Jun Lu
  • Yi ShaoEmail author
Original Paper


To evaluate the role of preoperative procalcitonin (PCT) levels in predicting postoperative fever after mini-percutaneous nephrolithotomy (mini-PCNL) in patients with a negative baseline urine culture. Between January 2014 and October 2017, 329 patients with a negative baseline urine culture and who underwent mini-PCNL were enrolled in this study. Patients were stratified into the control or febrile group based on a body temperature either less than or greater than 38 °C, respectively. Demographic and perioperative data were compared between the groups, and variables found to be statistically significant were included in a binary logistic regression analysis. A total of 68 (20.6%) patients experienced postoperative fever. The univariate analysis revealed a statistically significant difference between groups in preoperative fever (p = 0.032), stone burden (p < 0.001), C-reactive protein (p = 0.011), PCT (p < 0.001) and interleukin-6 (p = 0.035) levels. Binary logistic regression analysis indicated that stone burden > 353 mm3 (p = 0.003) and PCT > 0.05 ng/mL (p < 0.001) are independent risk factors for postoperative fever in mini-PCNL-treated patients with a negative baseline urine culture. We concluded that patients with stone burden > 353 mm3 or PCT > 0.05 ng/mL were more likely to develop postoperative fever after mini-PCNL, though with a negative baseline urine culture.


Percutaneous nephrolithotomy Postoperative fever Risk factors Procalcitonin 



This study was funded by the National Natural Science Foundation of China (Grant 81200504).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

For this type of study formal consent is not required.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Deng Li
    • 1
  • Minglei Sha
    • 2
  • Lei Chen
    • 1
  • Yinglong Xiao
    • 3
  • Jun Lu
    • 1
  • Yi Shao
    • 1
    Email author
  1. 1.Department of Urology, Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiPeople’s Republic of China
  2. 2.Department of Gerontology, Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiPeople’s Republic of China
  3. 3.Department of Urology, Shanghai General HospitalNanjing Medical UniversityShanghaiPeople’s Republic of China

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