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Urolithiasis

, Volume 47, Issue 2, pp 149–154 | Cite as

Polymorphisms of the VDR gene in patients with nephrolithiasis in a Han Chinese population

  • Zhenxing Yang
  • Qingqing Wang
  • Jiang F. Zhong
  • Longkun LiEmail author
Original Paper
  • 63 Downloads

Abstract

An association study between VDR gene polymorphisms and nephrolithiasis was conducted in different populations, but it is not yet known whether the association exists in the Han Chinese population. Here, we genotyped three SNPs (rs731236, rs7975232 and rs10735810) in the promoter region of the VDR gene by iMLDR genotyping assays in a large case–control cohort. The results demonstrated that there was no association found between the three SNPs (rs731236, rs7975232 and rs10735810) in the VDR gene and nephrolithiasis, whether in allele or genotype distribution. However, SNP rs10735810 was correlated with the level of serum calcium in control groups, but not in patient groups. In conclusion, considering the large sample size, we believe that the SNP rs10735810 allele A in the VDR gene promoter region may influence the level of serum calcium, but not influence the formation of nephrolithiasis in a Han Chinese population.

Keywords

VDR gene Nephrolithiasis Genetics 

Notes

Funding

Current work was supported partly by the National Natural Science Foundation of China (81470989 and 81600588), and partly by the clinical research project key projects of Second Affiliated Hospital, Third Military Medical University (2015YLC06).

Compliance with ethical standards

Conflict of interest

The authors declare no competing financial interest.

Ethical approval

This study was conducted with the approval of the ethics committee of Third Military Medical University.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Zhenxing Yang
    • 1
  • Qingqing Wang
    • 1
  • Jiang F. Zhong
    • 2
  • Longkun Li
    • 1
    Email author
  1. 1.Department of Urology, Second Affiliated HospitalThird Military Medical UniversityChongqingPeople’s Republic of China
  2. 2.Department of Pediatrics, Ostrow School of Dentistry, School of MedicineUniversity of Southern CaliforniaLos AngelesUSA

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