, Volume 46, Issue 6, pp 567–572 | Cite as

Do alpha-1 antagonist medications affect the success of semi-rigid ureteroscopy? A prospective, randomised, single-blind, multicentric study

  • Mustafa AydınEmail author
  • Muhammet Fatih Kılınç
  • Abdulmecit Yavuz
  • Göksel Bayar
Original Paper


The objective of this study is to assess the efficacy of adjunctive silodosin therapy in improving the success rate of semi-rigid ureteroscopy for removing ureteral stones. Prospective randomised controlled clinical trial performed between July 2016 and September 2016. All the patients underwent ureteroscopic holmium lithotripsy with a YAG laser. The patients were randomised into one of three groups: those who did not use an alpha-1 blocker (AB) (Group 1, n = 50), those who used an AB for one day (Group 2, n = 50), and those who used an AB for three days (Group 3, n = 47). The following information was recorded for each patient: the side, location, and surface area of the stone; successful access; operative success; complications; and operative time. There were no significant differences between the three groups in terms of demographics, stone location or size, and number of doses of an analgesic drug used. Access to the stone and the stone-free rate were significantly higher in group 3 (95.7, 93.6%) than in group 1 (76, 74%) and group 2 (78, 74%) (p = 0.018, p = 0.021), respectively. Balloon dilatation and complication rates were significantly lower in group 3 (12.8, 0%) than in group 1 (34, 12%) and group 2 (22, 4%) (p = 0.045, p = 0.029), respectively. The use of silodosin for 3 days before ureteroscopy for ureteral stones increased the rate of access to all ureter stones and decreased the complication rate.


Semi-rigid ureteroscopy Ureter stone Alpha-1 blocker Silodosin 


Compliance with ethical standards

Conflict of interest

No conflict of interest was declared by the authors.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Department of Urology, Samsun Training and Research HospitalUniversity of Health SciencesSamsunTurkey
  2. 2.Department of Urology, Ankara Training and Research HospitalUniversity of Health SciencesAnkaraTurkey
  3. 3.Department of UrologyHatay State HospitalHatayTurkey
  4. 4.Department of Urologyİdil State HospitalŞırnakTurkey

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