Urolithiasis

, Volume 44, Issue 3, pp 241–246 | Cite as

Clinical, demographic, and laboratory characteristics of children with nephrolithiasis

  • David J. Sas
  • Lauren J. Becton
  • Jeffrey Tutman
  • Laura A. Lindsay
  • Amy H. Wahlquist
Original Paper

Abstract

While the incidence of pediatric kidney stones appears to be increasing, little is known about the demographic, clinical, laboratory, imaging, and management variables in this patient population. We sought to describe various characteristics of our stone-forming pediatric population. To that end, we retrospectively reviewed the charts of pediatric patients with nephrolithiasis confirmed by imaging. Data were collected on multiple variables from each patient and analyzed for trends. For body mass index (BMI) controls, data from the general pediatrics population similar to our nephrolithiasis population were used. Data on 155 pediatric nephrolithiasis patients were analyzed. Of the 54 calculi available for analysis, 98 % were calcium based. Low urine volume, elevated supersaturation of calcium phosphate, elevated supersaturation of calcium oxalate, and hypercalciuria were the most commonly identified abnormalities on analysis of 24-h urine collections. Our stone-forming population did not have a higher BMI than our general pediatrics population, making it unlikely that obesity is a risk factor for nephrolithiasis in children. More girls presented with their first stone during adolescence, suggesting a role for reproductive hormones contributing to stone risk, while boys tended to present more commonly at a younger age, though this did not reach statistical significance. These intriguing findings warrant further investigation.

Keywords

Nephrolithiasis Urolithiasis Kidney stones Pediatrics Obesity Adolescents 

Supplementary material

240_2015_827_MOESM1_ESM.docx (11 kb)
Reference ranges for 24-hour urine samples (from Litholink Corporation, Chicago, IL unless referenced otherwise) (DOCX 11 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • David J. Sas
    • 1
  • Lauren J. Becton
    • 2
  • Jeffrey Tutman
    • 3
  • Laura A. Lindsay
    • 4
  • Amy H. Wahlquist
    • 5
  1. 1.Division of Pediatric Nephrology and Hypertension, Department of Pediatric and Adolescent MedicineMayo ClinicRochesterUSA
  2. 2.Division of Pediatric Nephrology, Department of PediatricsAlbert Einstein School of MedicineBronxUSA
  3. 3.University of Utah Department of RadiologySalt Lake CityUSA
  4. 4.Children’s Emergency ServicesDayton Children’s HospitalDaytonUSA
  5. 5.Division of Biostatistics and Epidemiology, Department of MedicineMedical University of South CarolinaCharlestonUSA

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